Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
1_MPPLL 6_ APLLC 11_ LALLP 16_ ALAAR 21_ GPRCS 26_ QPGET 31_ CLNGG 36_ KCEAA 41_ NGTEA 46_ CVCGG 51_ AFVGP 56_ RCQDP 61_ NPCLS 66_ TPCKN 71_ AGTCH 76_ VVDRR 81_ GVADY 86_ ACSCA 91_ LGFSG 96_ PLCLT 101_ PLDNA 106_ CLTNP 111_ CRNGG 116_ TCDLL 121_ TLTEY 126_ KCRCP 131_ PGWSG 136_ KSCQQ 141_ ADPCA 146_ SNPCA 151_ NGGQC 156_ LPFEA 161_ SYICH 166_ CPPSF 171_ HGPTC 176_ RQDVN 181_ ECGQK 186_ PGLCR 191_ HGGTC 196_ HNEVG 201_ SYRCV 206_ CRATH 211_ TGPNC 216_ ERPYV 221_ PCSPS 226_ PCQNG 231_ GTCRP 236_ TGDVT 241_ HECAC 246_ LPGFT 251_ GQNCE 256_ ENIDD 261_ CPGNN 266_ CKNGG 271_ ACVDG 276_ VNTYN 281_ CRCPP 286_ EWTGQ 291_ YCTED 296_ VDECQ 301_ LMPNA 306_ CQNGG 311_ TCHNT 316_ HGGYN 321_ CVCVN 326_ GWTGE 331_ DCSEN 336_ IDDCA 341_ SAACF 346_ HGATC 351_ HDRVA 356_ SFYCE 361_ CPHGR 366_ TGLLC 371_ HLNDA 376_ CISNP 381_ CNEGS 386_ NCDTN 391_ PVNGK 396_ AICTC 401_ PSGYT 406_ GPACS 411_ QDVDE 416_ CSLGA 421_ NPCEH 426_ AGKCI 431_ NTLGS 436_ FECQC 441_ LQGYT 446_ GPRCE 451_ IDVNE 456_ CVSNP 461_ CQNDA 466_ TCLDQ 471_ IGEFQ 476_ CICMP 481_ GYEGV 486_ HCEVN 491_ TDECA 496_ SSPCL 501_ HNGRC 506_ LDKIN 511_ EFQCE 516_ CPTGF 521_ TGHLC 526_ QYDVD 531_ ECAST 536_ PCKNG 541_ AKCLD 546_ GPNTY 551_ TCVCT 556_ EGYTG 561_ THCEV 566_ DIDEC 571_ DPDPC 576_ HYGSC 581_ KDGVA 586_ TFTCL 591_ CRPGY 596_ TGHHC 601_ ETNIN 606_ ECSSQ 611_ PCRHG 616_ GTCQD 621_ RDNAY 626_ LCFCL 631_ KGTTG 636_ PNCEI 641_ NLDDC 646_ ASSPC 651_ DSGTC 656_ LDKID 661_ GYECA 666_ CEPGY 671_ TGSMC 676_ NINID 681_ ECAGN 686_ PCHNG 691_ GTCED 696_ GINGF 701_ TCRCP 706_ EGYHD 711_ PTCLS 716_ EVNEC 721_ NSNPC 726_ VHGAC 731_ RDSLN 736_ GYKCD 741_ CDPGW 746_ SGTNC 751_ DINNN 756_ ECESN 761_ PCVNG 766_ GTCKD 771_ MTSGY 776_ VCTCR 781_ EGFSG 786_ PNCQT 791_ NINEC 796_ ASNPC 801_ LNQGT 806_ CIDDV 811_ AGYKC 816_ NCLLP 821_ YTGAT 826_ CEVVL 831_ APCAP 836_ SPCRN 841_ GGECR 846_ QSEDY 851_ ESFSC 856_ VCPTG 861_ WQGQT 866_ CEVDI 871_ NECVL 876_ SPCRH 881_ GASCQ 886_ NTHGG 891_ YRCHC 896_ QAGYS 901_ GRNCE 906_ TDIDD 911_ CRPNP 916_ CHNGG 921_ SCTDG 926_ INTAF 931_ CDCLP 936_ GFRGT 941_ FCEED 946_ INECA 951_ SDPCR 956_ NGANC 961_ TDCVD 966_ SYTCT 971_ CPAGF 976_ SGIHC 981_ ENNTP 986_ DCTES 991_ SCFNG 996_ GTCVD 1001_ GINSF 1006_ TCLCP 1011_ PGFTG 1016_ SYCQH 1021_ DVNEC 1026_ DSQPC 1031_ LHGGT 1036_ CQDGC 1041_ GSYRC 1046_ TCPQG 1051_ YTGPN 1056_ CQNLV 1061_ HWCDS 1066_ SPCKN 1071_ GGKCW 1076_ QTHTQ 1081_ YRCEC 1086_ PSGWT 1091_ GLYCD 1096_ VPSVS 1101_ CEVAA 1106_ QRQGV 1111_ DVARL 1116_ CQHGG 1121_ LCVDA 1126_ GNTHH 1131_ CRCQA 1136_ GYTGS 1141_ YCEDL 1146_ VDECS 1151_ PSPCQ 1156_ NGATC 1161_ TDYLG 1166_ GYSCK 1171_ CVAGY 1176_ HGVNC 1181_ SEEID 1186_ ECLSH 1191_ PCQNG 1196_ GTCLD 1201_ LPNTY 1206_ KCSCP 1211_ RGTQG 1216_ VHCEI 1221_ NVDDC 1226_ NPPVD 1231_ PVSRS 1236_ PKCFN 1241_ NGTCV 1246_ DQVGG 1251_ YSCTC 1256_ PPGFV 1261_ GERCE 1266_ GDVNE 1271_ CLSNP 1276_ CDARG 1281_ TQNCV 1286_ QRVND 1291_ FHCEC 1296_ RAGHT 1301_ GRRCE 1306_ SVING 1311_ CKGKP 1316_ CKNGG 1321_ TCAVA 1326_ SNTAR 1331_ GFICK 1336_ CPAGF 1341_ EGATC 1346_ ENDAR 1351_ TCGSL 1356_ RCLNG 1361_ GTCIS 1366_ GPRSP 1371_ TCLCL 1376_ GPFTG 1381_ PECQF 1386_ PASSP 1391_ CLGGN 1396_ PCYNQ 1401_ GTCEP 1406_ TSESP 1411_ FYRCL 1416_ CPAKF 1421_ NGLLC 1426_ HILDY 1431_ SFGGG 1436_ AGRDI 1441_ PPPLI 1446_ EEACE 1451_ LPECQ 1456_ EDAGN 1461_ KVCSL 1466_ QCNNH 1471_ ACGWD 1476_ GGDCS 1481_ LNFND 1486_ PWKNC 1491_ TQSLQ 1496_ CWKYF 1501_ SDGHC 1506_ DSQCN 1511_ SAGCL 1516_ FDGFD 1521_ CQRAE 1526_ GQCNP 1531_ LYDQY 1536_ CKDHF 1541_ SDGHC 1546_ DQGCN 1551_ SAECE 1556_ WDGLD 1561_ CAEHV 1566_ PERLA 1571_ AGTLV 1576_ VVVLM 1581_ PPEQL 1586_ RNSSF 1591_ HFLRE 1596_ LSRVL 1601_ HTNVV 1606_ FKRDA 1611_ HGQQM 1616_ IFPYY 1621_ GREEE 1626_ LRKHP 1631_ IKRAA 1636_ EGWAA 1641_ PDALL 1646_ GQVKA 1651_ SLLPG 1656_ GSEGG 1661_ RRRRE 1666_ LDPMD 1671_ VRGSI 1676_ VYLEI 1681_ DNRQC 1686_ VQASS 1691_ QCFQS 1696_ ATDVA 1701_ AFLGA 1706_ LASLG 1711_ SLNIP 1716_ YKIEA 1721_ VQSET 1726_ VEPPP 1731_ PAQLH 1736_ FMYVA 1741_ AAAFV 1746_ LLFFV 1751_ GCGVL 1756_ LSRKR 1761_ RRQHG 1766_ QLWFP 1771_ EGFKV 1776_ SEASK 1781_ KKRRE 1786_ PLGED 1791_ SVGLK 1796_ PLKNA 1801_ SDGAL 1806_ MDDNQ 1811_ NEWGD 1816_ EDLET 1821_ KKFRF 1826_ EEPVV 1831_ LPDLD 1836_ DQTDH 1841_ RQWTQ 1846_ QHLDA 1851_ ADLRM 1856_ SAMAP 1861_ TPPQG 1866_ EVDAD 1871_ CMDVN 1876_ VRGPD 1881_ GFTPL 1886_ MIASC 1891_ SGGGL 1896_ ETGNS 1901_ EEEED 1906_ APAVI 1911_ SDFIY 1916_ QGASL 1921_ HNQTD 1926_ RTGET 1931_ ALHLA 1936_ ARYSR 1941_ SDAAK 1946_ RLLEA 1951_ SADAN 1956_ IQDNM 1961_ GRTPL 1966_ HAAVS 1971_ ADAQG 1976_ VFQIL 1981_ IRNRA 1986_ TDLDA 1991_ RMHDG 1996_ TTPLI 2001_ LAARL 2006_ AVEGM 2011_ LEDLI 2016_ NSHAD 2021_ VNAVD 2026_ DLGKS 2031_ ALHWA 2036_ AAVNN 2041_ VDAAV 2046_ VLLKN 2051_ GANKD 2056_ MQNNR 2061_ EETPL 2066_ FLAAR 2071_ EGSYE 2076_ TAKVL 2081_ LDHFA 2086_ NRDIT 2091_ DHMDR 2096_ LPRDI 2101_ AQERM 2106_ HHDIV 2111_ RLLDE 2116_ YNLVR 2121_ SPQLH 2126_ GAPLG 2131_ GTPTL 2136_ SPPLC 2141_ SPNGY 2146_ LGSLK 2151_ PGVQG 2156_ KKVRK 2161_ PSSKG 2166_ LACGS 2171_ KEAKD 2176_ LKARR 2181_ KKSQD 2186_ GKGCL 2191_ LDSSG 2196_ MLSPV 2201_ DSLES 2206_ PHGYL 2211_ SDVAS 2216_ PPLLP 2221_ SPFQQ 2226_ SPSVP 2231_ LNHLP 2236_ GMPDT 2241_ HLGIG 2246_ HLNVA 2251_ AKPEM 2256_ AALGG 2261_ GGRLA 2266_ FETGP 2271_ PRLSH 2276_ LPVAS 2281_ GTSTV 2286_ LGSSS 2291_ GGALN 2296_ FTVGG 2301_ STSLN 2306_ GQCEW 2311_ LSRLQ 2316_ SGMVP 2321_ NQYNP 2326_ LRGSV 2331_ APGPL 2336_ STQAP 2341_ SLQHG 2346_ MVGPL 2351_ HSSLA 2356_ ASALS 2361_ QMMSY 2366_ QGLPS 2371_ TRLAT 2376_ QPHLV 2381_ QTQQV 2386_ QPQNL 2391_ QMQQQ 2396_ NLQPA 2401_ NIQQQ 2406_ QSLQP 2411_ PPPPP 2416_ QPHLG 2421_ VSSAA 2426_ SGHLG 2431_ RSFLS 2436_ GEPSQ 2441_ ADVQP 2446_ LGPSS 2451_ LAVHT 2456_ ILPQE 2461_ SPALP 2466_ TSLPS 2471_ SLVPP 2476_ VTAAQ 2481_ FLTPP 2486_ SQHSY 2491_ SSPVD 2496_ NTPSH 2501_ QLQVP 2506_ EHPFL 2511_ TPSPE 2516_ SPDQW 2521_ SSSSP 2526_ HSNVS 2531_ DWSEG 2536_ VSSPP 2541_ TSMQS 2546_QIARI
1: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO)