Radiation-inducible immediate-early gene IEX-1 (Differentiation-dependent gene 2 protein) (Protein DIF-2) (Immediate early protein GLY96) (Immediate early response 3 protein) (PACAP-responsive gene 1 protein) (Protein PRG1)
1_MCHSR 6_ SCHPT 11_ MTILQ 16_ APTPA 21_ PSTIP 26_ GPRRG 31_ SGPEI 36_ FTFDP 41_ LPEPA 46_ AAPAG 51_ RPSAS 56_ RGHRK 61_ RSRRV 66_ LYPRV 71_ VRRQL 76_ PVEEP 81_ NPAKR 86_ LLFLL 91_ LTIVF 96_ CQILM 101_ AEEGV 106_ PAPLP 111_ PEDAP 116_ NAASL 121_ APTPV 126_ SAVLE 131_ PFNLT 136_ SEPSD 141_ YALDL 146_ STFLQ 151_QHPAA
1: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Also acts as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment