Solute carrier organic anion transporter family member 1A2 (OATP-A) (Organic anion-transporting polypeptide 1) (OATP-1) (Sodium-independent organic anion transporter) (Solute carrier family 21 member 3)
1_MGETE 6_ KRIET 11_ HRIRC 16_ LSKLK 21_ MFLLA 26_ ITCAF 31_ VSKTL 36_ SGSYM 41_ NSMLT 46_ QIERQ 51_ FNIPT 56_ SLVGF 61_ INGSF 66_ EIGNL 71_ LLIIF 76_ VSYFG 81_ TKLHR 86_ PIMIG 91_ IGCVV 96_ MGLGC 101_ FLKSL 106_ PHFLM 111_ NQYEY 116_ ESTVS 121_ VSGNL 126_ SSNSF 131_ LCMEN 136_ GTQIL 141_ RPTQD 146_ PSECT 151_ KEVKS 156_ LMWVY 161_ VLVGN 166_ IVRGM 171_ GETPI 176_ LPLGI 181_ SYIED 186_ FAKFE 191_ NSPLY 196_ IGLVE 201_ TGAII 206_ GPLIG 211_ LLLAS 216_ FCANV 221_ YVDTG 226_ FVNTD 231_ DLIIT 236_ PTDTR 241_ WVGAW 246_ WFGFL 251_ ICAGV 256_ NVLTA 261_ IPFFF 266_ LPNTL 271_ PKEGL 276_ ETNAD 281_ IIKNE 286_ NEDKQ 291_ KEEVK 296_ KEKYG 301_ ITKDF 306_ LPFMK 311_ SLSCN 316_ PIYML 321_ FILVS 326_ VIQFN 331_ AFVNM 336_ ISFMP 341_ KYLEQ 346_ QYGIS 351_ SSDAI 356_ FLMGI 361_ YNLPP 366_ ICIGY 371_ IIGGL 376_ IMKKF 381_ KITVK 386_ QAAHI 391_ GCWLS 396_ LLEYL 401_ LYFLS 406_ FLMTC 411_ ENSSV 416_ VGINT 421_ SYEGI 426_ PQDLY 431_ VENDI 436_ FADCN 441_ VDCNC 446_ PSKIW 451_ DPVCG 456_ NNGLS 461_ YLSAC 466_ LAGCE 471_ TSIGT 476_ GINMV 481_ FQNCS 486_ CIQTS 491_ GNSSA 496_ VLGLC 501_ DKGPD 506_ CSLML 511_ QYFLI 516_ LSAMS 521_ SFIYS 526_ LAAIP 531_ GYMVL 536_ LRCMK 541_ SEEKS 546_ LGVGL 551_ HTFCT 556_ RVFAG 561_ IPAPI 566_ YFGAL 571_ MDSTC 576_ LHWGT 581_ LKCGE 586_ SGACR 591_ IYDST 596_ TFRYI 601_ YLGLP 606_ AALRG 611_ SSFVP 616_ ALIIL 621_ ILLRK 626_ CHLPG 631_ ENASS 636_ GTELI 641_ ETKVK 646_ GKENE 651_ CKDIY 656_ QKSTV 661_LKDDE
1: Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane (PubMed:19129463, PubMed:7557095). Responsible for intestinal absorption of bile acids (By similarity). Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate) (PubMed:11159893, PubMed:12568656, PubMed:19129463, PubMed:23918469, PubMed:25560245, PubMed:9539145). Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision (PubMed:25560245). Involved in the uptake of clinically used drugs (PubMed:17301733, PubMed:20686826, PubMed:27777271). Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine) (PubMed:19129463, PubMed:20358049). Also transports prostaglandin E2 (PubMed:19129463). Plays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (By similarity). May also play a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (PubMed:25132355). May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel (PubMed:23243220). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable)