Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)
1_MESPA 6_ SSQPA 11_ SMPQS 16_ KGKSK 21_ RKKDL 26_ RISCM 31_ SKPPA 36_ PNPTP 41_ PRNLD 46_ SRTFI 51_ TIGDR 56_ NFEVE 61_ ADDLV 66_ TISEL 71_ GRGAY 76_ GVVEK 81_ VRHAQ 86_ SGTIM 91_ AVKRI 96_ RATVN 101_ SQEQK 106_ RLLMD 111_ LDINM 116_ RTVDC 121_ FYTVT 126_ FYGAL 131_ FREGD 136_ VWICM 141_ ELMDT 146_ SLDKF 151_ YRKVL 156_ DKNMT 161_ IPEDI 166_ LGEIA 171_ VSIVR 176_ ALEHL 181_ HSKLS 186_ VIHRD 191_ VKPSN 196_ VLINK 201_ EGHVK 206_ MCDFG 211_ ISGYL 216_ VDSVA 221_ KTMDA 226_ GCKPY 231_ MAPER 236_ INPEL 241_ NQKGY 246_ NVKSD 251_ VWSLG 256_ ITMIE 261_ MAILR 266_ FPYES 271_ WGTPF 276_ QQLKQ 281_ VVEEP 286_ SPQLP 291_ ADRFS 296_ PEFVD 301_ FTAQC 306_ LRKNP 311_ AERMS 316_ YLELM 321_ EHPFF 326_ TLHKT 331_ KKTDI 336_ AAFVK 341_EILGE
1: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14