60S ribosomal protein L5 (Large ribosomal subunit protein uL18)
1_MGFVK 6_ VVKNK 11_ AYFKR 16_ YQVKF 21_ RRRRE 26_ GKTDY 31_ YARKR 36_ LVIQD 41_ KNKYN 46_ TPKYR 51_ MIVRV 56_ TNRDI 61_ ICQIA 66_ YARIE 71_ GDMIV 76_ CAAYA 81_ HELPK 86_ YGVKV 91_ GLTNY 96_ AAAYC 101_ TGLLL 106_ ARRLL 111_ NRFGM 116_ DKIYE 121_ GQVEV 126_ TGDEY 131_ NVESI 136_ DGQPG 141_ AFTCY 146_ LDAGL 151_ ARTTT 156_ GNKVF 161_ GALKG 166_ AVDGG 171_ LSIPH 176_ STKRF 181_ PGYDS 186_ ESKEF 191_ NAEVH 196_ RKHIM 201_ GQNVA 206_ DYMRY 211_ LMEED 216_ EDAYK 221_ KQFSQ 226_ YIKNS 231_ VTPDM 236_ MEEMY 241_ KKAHA 246_ AIREN 251_ PVYEK 256_ KPKKE 261_ VKKKR 266_ WNRPK 271_ MSLAQ 276_ KKDRV 281_ AQKKA 286_ SFLRA 291_QERAA
1: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (PubMed:12962325, PubMed:19061985, PubMed:23636399, PubMed:24120868). It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (PubMed:24120868)