Glucosamine-6-phosphate isomerase 1 (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase 1) (GNPDA 1) (GlcN6P deaminase 1) (Oscillin)
1_MKLII 6_ LEHYS 11_ QASEW 16_ AAKYI 21_ RNRII 26_ QFNPG 31_ PEKYF 36_ TLGLP 41_ TGSTP 46_ LGCYK 51_ KLIEY 56_ YKNGD 61_ LSFKY 66_ VKTFN 71_ MDEYV 76_ GLPRD 81_ HPESY 86_ HSFMW 91_ NNFFK 96_ HIDIH 101_ PENTH 106_ ILDGN 111_ AVDLQ 116_ AECDA 121_ FEEKI 126_ KAAGG 131_ IELFV 136_ GGIGP 141_ DGHIA 146_ FNEPG 151_ SSLVS 156_ RTRVK 161_ TLAMD 166_ TILAN 171_ ARFFD 176_ GELTK 181_ VPTMA 186_ LTVGV 191_ GTVMD 196_ AREVM 201_ ILITG 206_ AHKAF 211_ ALYKA 216_ IEEGV 221_ NHMWT 226_ VSAFQ 231_ QHPRT 236_ VFVCD 241_ EDATL 246_ ELKVK 251_ TVKYF 256_ KGLML 261_ VHNKL 266_ VDPLY 271_ SIKEK 276_ ETEKS 281_QSSKK
1: Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis (PubMed:21807125, PubMed:26887390). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling (PubMed:26887390). Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity)