Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
1_MDPGQ 6_ QPPPQ 11_ PAPQG 16_ QGQPP 21_ SQPPQ 26_ GQGPP 31_ SGPGQ 36_ PAPAA 41_ TQAAP 46_ QAPPA 51_ GHQIV 56_ HVRGD 61_ SETDL 66_ EALFN 71_ AVMNP 76_ KTANV 81_ PQTVP 86_ MRLRK 91_ LPDSF 96_ FKPPE 101_ PKSHS 106_ RQAST 111_ DAGTA 116_ GALTP 121_ QHVRA 126_ HSSPA 131_ SLQLG 136_ AVSPG 141_ TLTPT 146_ GVVSG 151_ PAATP 156_ TAQHL 161_ RQSSF 166_ EIPDD 171_ VPLPA 176_ GWEMA 181_ KTSSG 186_ QRYFL 191_ NHIDQ 196_ TTTWQ 201_ DPRKA 206_ MLSQM 211_ NVTAP 216_ TSPPV 221_ QQNMM 226_ NSASG 231_ PLPDG 236_ WEQAM 241_ TQDGE 246_ IYYIN 251_ HKNKT 256_ TSWLD 261_ PRLDP 266_ RFAMN 271_ QRISQ 276_ SAPVK 281_ QPPPL 286_ APQSP 291_ QGGVM 296_ GGSNS 301_ NQQQQ 306_ MRLQQ 311_ LQMEK 316_ ERLRL 321_ KQQEL 326_ LRQAM 331_ RNINP 336_ STANS 341_ PKCQE 346_ LALRS 351_ QLPTL 356_ EQDGG 361_ TQNPV 366_ SSPGM 371_ SQELR 376_ TMTTN 381_ SSDPF 386_ LNSGT 391_ YHSRD 396_ ESTDS 401_ GLSMS 406_ SYSVP 411_ RTPDD 416_ FLNSV 421_ DEMDT 426_ GDTIN 431_ QSTLP 436_ SQQNR 441_ FPDYL 446_ EAIPG 451_ TNVDL 456_ GTLEG 461_ DGMNI 466_ EGEEL 471_ MPSLQ 476_ EALSS 481_ DILND 486_ MESVL 491_ AATKL 496_DKESF
1: Transcriptional regulator with dual roles as a coactivator and corepressor. Critical downstream regulatory target in the Hippo signaling pathway, crucial for organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637, PubMed:30447097). The Hippo signaling pathway core involves a kinase cascade featuring STK3/MST2 and STK4/MST1, along with its regulatory partner SAV1, which phosphorylates and activates LATS1/2 in complex with their regulatory protein, MOB1. This activation leads to the phosphorylation and inactivation of the YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Phosphorylation of YAP1 by LATS1/2 prevents its nuclear translocation, thereby regulating the expression of its target genes (PubMed:18158288, PubMed:26598551, PubMed:34404733). The transcriptional regulation of gene expression requires TEAD transcription factors and modulates cell growth, anchorage-independent growth, and induction of epithelial-mesenchymal transition (EMT) (PubMed:18579750). Plays a key role in tissue tension and 3D tissue shape by regulating the cortical actomyosin network, acting via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). It also suppresses ciliogenesis by acting as a transcriptional corepressor of TEAD4 target genes AURKA and PLK1 (PubMed:25849865). In conjunction with WWTR1, regulates TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). Synergizes with WBP2 to enhance PGR activity (PubMed:16772533)
2: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3)
3: Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3)