Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]
1_MSFID 6_ PYQHI 11_ IVEHQ 16_ YSHKF 21_ TVVVL 26_ RATKV 31_ TKGAF 36_ GDMLD 41_ TPDPY 46_ VELFI 51_ STTPD 56_ SRKRT 61_ RHFNN 66_ DINPV 71_ WNETF 76_ EFILD 81_ PNQEN 86_ VLEIT 91_ LMDAN 96_ YVMDE 101_ TLGTA 106_ TFTVS 111_ SMKVG 116_ EKKEV 121_ PFIFN 126_ QVTEM 131_ VLEMS 136_ LEVCS 141_ CPDLR 146_ FSMAL 151_ CDQEK 156_ TFRQQ 161_ RKEHI 166_ RESMK 171_ KLLGP 176_ KNSEG 181_ LHSAR 186_ DVPVV 191_ AILGS 196_ GGGFR 201_ AMVGF 206_ SGVMK 211_ ALYES 216_ GILDC 221_ ATYVA 226_ GLSGS 231_ TWYMS 236_ TLYSH 241_ PDFPE 246_ KGPEE 251_ INEEL 256_ MKNVS 261_ HNPLL 266_ LLTPQ 271_ KVKRY 276_ VESLW 281_ KKKSS 286_ GQPVT 291_ FTDIF 296_ GMLIG 301_ ETLIH 306_ NRMNT 311_ TLSSL 316_ KEKVN 321_ TAQCP 326_ LPLFT 331_ CLHVK 336_ PDVSE 341_ LMFAD 346_ WVEFS 351_ PYEIG 356_ MAKYG 361_ TFMAP 366_ DLFGS 371_ KFFMG 376_ TVVKK 381_ YEENP 386_ LHFLM 391_ GVWGS 396_ AFSIL 401_ FNRVL 406_ GVSGS 411_ QSRGS 416_ TMEEE 421_ LENIT 426_ TKHIV 431_ SNDSS 436_ DSDDE 441_ SHEPK 446_ GTENE 451_ DAGSD 456_ YQSDN 461_ QASWI 466_ HRMIM 471_ ALVSD 476_ SALFN 481_ TREGR 486_ AGKVH 491_ NFMLG 496_ LNLNT 501_ SYPLS 506_ PLSDF 511_ ATQDS 516_ FDDDE 521_ LDAAV 526_ ADPDE 531_ FERIY 536_ EPLDV 541_ KSKKI 546_ HVVDS 551_ GLTFN 556_ LPYPL 561_ ILRPQ 566_ RGVDL 571_ IISFD 576_ FSARP 581_ SDSSP 586_ PFKEL 591_ LLAEK 596_ WAKMN 601_ KLPFP 606_ KIDPY 611_ VFDRE 616_ GLKEC 621_ YVFKP 626_ KNPDM 631_ EKDCP 636_ TIIHF 641_ VLANI 646_ NFRKY 651_ RAPGV 656_ PRETE 661_ EEKEI 666_ ADFDI 671_ FDDPE 676_ SPFST 681_ FNFQY 686_ PNQAF 691_ KRLHD 696_ LMHFN 701_ TLNNI 706_ DVIKE 711_ AMVES 716_ IEYRR 721_ QNPSR 726_ CSVSL 731_ SNVEA 736_ RRFFN 741_KEFLS
1: Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:8619991, PubMed:9425121). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed:10358058, PubMed:17472963, PubMed:18451993, PubMed:7794891, PubMed:9425121). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed:27642067). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed:7794891). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed:12672805). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed:7794891)