F-actin-capping protein subunit beta (CapZ beta)
1_MSDQQ 6_ LDCAL 11_ DLMRR 16_ LPPQQ 21_ IEKNL 26_ SDLID 31_ LVPSL 36_ CEDLL 41_ SSVDQ 46_ PLKIA 51_ RDKVV 56_ GKDYL 61_ LCDYN 66_ RDGDS 71_ YRSPW 76_ SNKYD 81_ PPLED 86_ GAMPS 91_ ARLRK 96_ LEVEA 101_ NNAFD 106_ QYRDL 111_ YFEGG 116_ VSSVY 121_ LWDLD 126_ HGFAG 131_ VILIK 136_ KAGDG 141_ SKKIK 146_ GCWDS 151_ IHVVE 156_ VQEKS 161_ SGRTA 166_ HYKLT 171_ STVML 176_ WLQTN 181_ KSGSG 186_ TMNLG 191_ GSLTR 196_ QMEKD 201_ ETVSD 206_ CSPHI 211_ ANIGR 216_ LVEDM 221_ ENKIR 226_ STLNE 231_ IYFGK 236_ TKDIV 241_ NGLRS 246_ IDAIP 251_ DNQKF 256_ KQLQR 261_ ELSQV 266_ LTQRQ 271_IYIQP
1: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)