Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2)
1_MKTKL 6_ NIYNM 11_ QFLLF 16_ VFLVW 21_ DPARL 26_ VLANI 31_ QEDEA 36_ KNNIT 41_ IFTRI 46_ LDRLL 51_ DGYDN 56_ RLRPG 61_ LGDSI 66_ TEVFT 71_ NIYVT 76_ SFGPV 81_ SDTDM 86_ EYTID 91_ VFFRQ 96_ KWKDE 101_ RLKFK 106_ GPMNI 111_ LRLNN 116_ LMASK 121_ IWTPD 126_ TFFHN 131_ GKKSV 136_ AHNMT 141_ MPNKL 146_ LRIQD 151_ DGTLL 156_ YTMRL 161_ TVQAE 166_ CPMHL 171_ EDFPM 176_ DAHSC 181_ PLKFG 186_ SYAYT 191_ TSEVT 196_ YIWTY 201_ NASDS 206_ VQVAP 211_ DGSRL 216_ NQYDL 221_ LGQSI 226_ GKETI 231_ KSSTG 236_ EYTVM 241_ TAHFH 246_ LKRKI 251_ GYFVI 256_ QTYLP 261_ CIMTV 266_ ILSQV 271_ SFWLN 276_ RESVP 281_ ARTVF 286_ GVTTV 291_ LTMTT 296_ LSISA 301_ RNSLP 306_ KVAYA 311_ TAMDW 316_ FIAVC 321_ YAFVF 326_ SALIE 331_ FATVN 336_ YFTKR 341_ GWAWD 346_ GKSVV 351_ NDKKK 356_ EKASV 361_ MIQNN 366_ AYAVA 371_ VANYA 376_ PNLSK 381_ DPVLS 386_ TISKS 391_ ATTPE 396_ PNKKP 401_ ENKPA 406_ EAKKT 411_ FNSVS 416_ KIDRM 421_ SRIVF 426_ PVLFG 431_ TFNLV 436_ YWATY 441_ LNREP 446_VLGVS
1: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:29961870, PubMed:31032849). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10449790). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity)