Gamma-aminobutyric acid receptor subunit beta-2 (GABA(A) receptor subunit beta-2)
1_MWRVR 6_ KRGYF 11_ GIWSF 16_ PLIIA 21_ AVCAQ 26_ SVNDP 31_ SNMSL 36_ VKETV 41_ DRLLK 46_ GYDIR 51_ LRPDF 56_ GGPPV 61_ AVGMN 66_ IDIAS 71_ IDMVS 76_ EVNMD 81_ YTLTM 86_ YFQQA 91_ WRDKR 96_ LSYNV 101_ IPLNL 106_ TLDNR 111_ VADQL 116_ WVPDT 121_ YFLND 126_ KKSFV 131_ HGVTV 136_ KNRMI 141_ RLHPD 146_ GTVLY 151_ GLRIT 156_ TTAAC 161_ MMDLR 166_ RYPLD 171_ EQNCT 176_ LEIES 181_ YGYTT 186_ DDIEF 191_ YWRGD 196_ DNAVT 201_ GVTKI 206_ ELPQF 211_ SIVDY 216_ KLITK 221_ KVVFS 226_ TGSYP 231_ RLSLS 236_ FKLKR 241_ NIGYF 246_ ILQTY 251_ MPSIL 256_ ITILS 261_ WVSFW 266_ INYDA 271_ SAARV 276_ ALGIT 281_ TVLTM 286_ TTINT 291_ HLRET 296_ LPKIP 301_ YVKAI 306_ DMYLM 311_ GCFVF 316_ VFMAL 321_ LEYAL 326_ VNYIF 331_ FGRGP 336_ QRQKK 341_ AAEKA 346_ ASANN 351_ EKMRL 356_ DVNKI 361_ FYKDI 366_ KQNGT 371_ QYRSL 376_ WDPTG 381_ NLSPT 386_ RRTTN 391_ YDFSL 396_ YTMDP 401_ HENIL 406_ LSTLE 411_ IKNEM 416_ ATSEA 421_ VMGLG 426_ DPRST 431_ MLAYD 436_ ASSIQ 441_ YRKAG 446_ LPRHS 451_ FGRNA 456_ LERHV 461_ AQKKS 466_ RLRRR 471_ ASQLK 476_ ITIPD 481_ LTDVN 486_ AIDRW 491_ SRIFF 496_ PVVFS 501_ FFNIV 506_YWLYY
1: Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:19763268, PubMed:27789573, PubMed:29950725, PubMed:8264558). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:29950725). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:23909897, PubMed:25489750). Extrasynaptic beta-2 receptors contribute to the tonic GABAergic inhibition (By similarity). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity)