Glucagon receptor (GL-R)
1_MPPCQ 6_ PQRPL 11_ LLLLL 16_ LLACQ 21_ PQVPS 26_ AQVMD 31_ FLFEK 36_ WKLYG 41_ DQCHH 46_ NLSLL 51_ PPPTE 56_ LVCNR 61_ TFDKY 66_ SCWPD 71_ TPANT 76_ TANIS 81_ CPWYL 86_ PWHHK 91_ VQHRF 96_ VFKRC 101_ GPDGQ 106_ WVRGP 111_ RGQPW 116_ RDASQ 121_ CQMDG 126_ EEIEV 131_ QKEVA 136_ KMYSS 141_ FQVMY 146_ TVGYS 151_ LSLGA 156_ LLLAL 161_ AILGG 166_ LSKLH 171_ CTRNA 176_ IHANL 181_ FASFV 186_ LKASS 191_ VLVID 196_ GLLRT 201_ RYSQK 206_ IGDDL 211_ SVSTW 216_ LSDGA 221_ VAGCR 226_ VAAVF 231_ MQYGI 236_ VANYC 241_ WLLVE 246_ GLYLH 251_ NLLGL 256_ ATLPE 261_ RSFFS 266_ LYLGI 271_ GWGAP 276_ MLFVV 281_ PWAVV 286_ KCLFE 291_ NVQCW 296_ TSNDN 301_ MGFWW 306_ ILRFP 311_ VFLAI 316_ LINFF 321_ IFVRI 326_ VQLLV 331_ AKLRA 336_ RQMHH 341_ TDYKF 346_ RLAKS 351_ TLTLI 356_ PLLGV 361_ HEVVF 366_ AFVTD 371_ EHAQG 376_ TLRSA 381_ KLFFD 386_ LFLSS 391_ FQGLL 396_ VAVLY 401_ CFLNK 406_ EVQSE 411_ LRRRW 416_ HRWRL 421_ GKVLW 426_ EERNT 431_ SNHRA 436_ SSSPG 441_ HGPPS 446_ KELQF 451_ GRGGG 456_ SQDSS 461_ AETPL 466_ AGGLP 471_RLAES
1: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system