Secretin receptor (SCT-R)
1_MRPHL 6_ SPPLQ 11_ QLLLP 16_ VLLAC 21_ AAHST 26_ GALPR 31_ LCDVL 36_ QVLWE 41_ EQDQC 46_ LQELS 51_ REQTG 56_ DLGTE 61_ QPVPG 66_ CEGMW 71_ DNISC 76_ WPSSV 81_ PGRMV 86_ EVECP 91_ RFLRM 96_ LTSRN 101_ GSLFR 106_ NCTQD 111_ GWSET 116_ FPRPN 121_ LACGV 126_ NVNDS 131_ SNEKR 136_ HSYLL 141_ KLKVM 146_ YTVGY 151_ SSSLV 156_ MLLVA 161_ LGILC 166_ AFRRL 171_ HCTRN 176_ YIHMH 181_ LFVSF 186_ ILRAL 191_ SNFIK 196_ DAVLF 201_ SSDDV 206_ TYCDA 211_ HRAGC 216_ KLVMV 221_ LFQYC 226_ IMANY 231_ SWLLV 236_ EGLYL 241_ HTLLA 246_ ISFFS 251_ ERKYL 256_ QGFVA 261_ FGWGS 266_ PAIFV 271_ ALWAI 276_ ARHFL 281_ EDVGC 286_ WDINA 291_ NASIW 296_ WIIRG 301_ PVILS 306_ ILINF 311_ ILFIN 316_ ILRIL 321_ MRKLR 326_ TQETR 331_ GNEVS 336_ HYKRL 341_ ARSTL 346_ LLIPL 351_ FGIHY 356_ IVFAF 361_ SPEDA 366_ MEIQL 371_ FFELA 376_ LGSFQ 381_ GLVVA 386_ VLYCF 391_ LNGEV 396_ QLEVQ 401_ KKWQQ 406_ WHLRE 411_ FPLHP 416_ VASFS 421_ NSTKA 426_ SHLEQ 431_SQGTC
1: G protein-coupled receptor activated by secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:25332973, PubMed:32811827, PubMed:33008599, PubMed:7612008). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and activates cAMP-dependent pathway (PubMed:32811827, PubMed:33008599). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity)