Aldehyde dehydrogenase family 1 member A3 (EC 1.2.1.36) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3) (RalDH3)
1_MATAN 6_ GAVEN 11_ GQPDR 16_ KPPAL 21_ PRPIR 26_ NLEVK 31_ FTKIF 36_ INNEW 41_ HESKS 46_ GKKFA 51_ TCNPS 56_ TREQI 61_ CEVEE 66_ GDKPD 71_ VDKAV 76_ EAAQV 81_ AFQRG 86_ SPWRR 91_ LDALS 96_ RGRLL 101_ HQLAD 106_ LVERD 111_ RATLA 116_ ALETM 121_ DTGKP 126_ FLHAF 131_ FIDLE 136_ GCIRT 141_ LRYFA 146_ GWADK 151_ IQGKT 156_ IPTDD 161_ NVVCF 166_ TRHEP 171_ IGVCG 176_ AITPW 181_ NFPLL 186_ MLVWK 191_ LAPAL 196_ CCGNT 201_ MVLKP 206_ AEQTP 211_ LTALY 216_ LGSLI 221_ KEAGF 226_ PPGVV 231_ NIVPG 236_ FGPTV 241_ GAAIS 246_ SHPQI 251_ NKIAF 256_ TGSTE 261_ VGKLV 266_ KEAAS 271_ RSNLK 276_ RVTLE 281_ LGGKN 286_ PCIVC 291_ ADADL 296_ DLAVE 301_ CAHQG 306_ VFFNQ 311_ GQCCT 316_ AASRV 321_ FVEEQ 326_ VYSEF 331_ VRRSV 336_ EYAKK 341_ RPVGD 346_ PFDVK 351_ TEQGP 356_ QIDQK 361_ QFDKI 366_ LELIE 371_ SGKKE 376_ GAKLE 381_ CGGSA 386_ MEDKG 391_ LFIKP 396_ TVFSE 401_ VTDNM 406_ RIAKE 411_ EIFGP 416_ VQPIL 421_ KFKSI 426_ EEVIK 431_ RANST 436_ DYGLT 441_ AAVFT 446_ KNLDK 451_ ALKLA 456_ SALES 461_ GTVWI 466_ NCYNA 471_ LYAQA 476_ PFGGF 481_ KMSGN 486_ GRELG 491_ EYALA 496_ EYTEV 501_ KTVTI 506_KLGDK
1: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (By similarity) (PubMed:27759097). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (PubMed:27759097). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (By similarity)