5-hydroxytryptamine receptor 5A (5-HT-5) (5-HT-5A) (5-HT5A) (Serotonin receptor 5A)
1_MDLPV 6_ NLTSF 11_ SLSTP 16_ SPLET 21_ NHSLG 26_ KDDLR 31_ PSSPL 36_ LSVFG 41_ VLILT 46_ LLGFL 51_ VAATF 56_ AWNLL 61_ VLATI 66_ LRVRT 71_ FHRVP 76_ HNLVA 81_ SMAVS 86_ DVLVA 91_ ALVMP 96_ LSLVH 101_ ELSGR 106_ RWQLG 111_ RRLCQ 116_ LWIAC 121_ DVLCC 126_ TASIW 131_ NVTAI 136_ ALDRY 141_ WSITR 146_ HMEYT 151_ LRTRK 156_ CVSNV 161_ MIALT 166_ WALSA 171_ VISLA 176_ PLLFG 181_ WGETY 186_ SEGSE 191_ ECQVS 196_ REPSY 201_ AVFST 206_ VGAFY 211_ LPLCV 216_ VLFVY 221_ WKIYK 226_ AAKFR 231_ VGSRK 236_ TNSVS 241_ PISEA 246_ VEVKD 251_ SAKQP 256_ QMVFT 261_ VRHAT 266_ VTFQP 271_ EGDTW 276_ REQKE 281_ QRAAL 286_ MVGIL 291_ IGVFV 296_ LCWIP 301_ FFLTE 306_ LISPL 311_ CSCDI 316_ PAIWK 321_ SIFLW 326_ LGYSN 331_ SFFNP 336_ LIYTA 341_ FNKNY 346_ NSAFK 351_NFFSR
1: G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35610220, PubMed:35835867, PubMed:9865521). Also functions as a receptor for ergot alkaloid derivatives and other psychoactive substances (PubMed:35835867). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35610220, PubMed:35835867, PubMed:9865521). HTR5A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:35610220, PubMed:35835867, PubMed:9865521)