Homeobox protein CDX-1 (Caudal-type homeobox protein 1)
1_MYVGY 6_ VLDKD 11_ SPVYP 16_ GPARP 21_ ASLGL 26_ GPQAY 31_ GPPAP 36_ PPAPP 41_ QYPDF 46_ SSYSH 51_ VEPAP 56_ APPTA 61_ WGAPF 66_ PAPKD 71_ DWAAA 76_ YGPGP 81_ AAPAA 86_ SPASL 91_ AFGPP 96_ PDFSP 101_ VPAPP 106_ GPGPG 111_ LLAQP 116_ LGGPG 121_ TPSSP 126_ GAQRP 131_ TPYEW 136_ MRRSV 141_ AAGGG 146_ GGSGK 151_ TRTKD 156_ KYRVV 161_ YTDHQ 166_ RLELE 171_ KEFHY 176_ SRYIT 181_ IRRKS 186_ ELAAN 191_ LGLTE 196_ RQVKI 201_ WFQNR 206_ RAKER 211_ KVNKK 216_ KQQQQ 221_ QPPQP 226_ PMAHD 231_ ITATP 236_ AGPSL 241_ GGLCP 246_ SNTSL 251_ LATSS 256_PMPVK
1: Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536)