mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2)
1_MSTTL 6_ LSAFY 11_ DVDFL 16_ CKTEK 21_ SLANL 26_ NLNNM 31_ LDKKA 36_ VGTPV 41_ AAAPS 46_ SGFAP 51_ GFLRR 56_ HSASN 61_ LHALA 66_ HPAPS 71_ PGSCS 76_ PKFPG 81_ AANGS 86_ SCGSA 91_ AAGGP 96_ TSYGT 101_ LKEPS 106_ GGGGT 111_ ALLNK 116_ ENKFR 121_ DRSFS 126_ ENGDR 131_ SQHLL 136_ HLQQQ 141_ QKGGG 146_ GSQIN 151_ STRYK 156_ TELCR 161_ PFEES 166_ GTCKY 171_ GEKCQ 176_ FAHGF 181_ HELRS 186_ LTRHP 191_ KYKTE 196_ LCRTF 201_ HTIGF 206_ CPYGP 211_ RCHFI 216_ HNADE 221_ RRPAP 226_ SGGAS 231_ GDLRA 236_ FGTRD 241_ ALHLG 246_ FPREP 251_ RPKLH 256_ HSLSF 261_ SGFPS 266_ GHHQP 271_ PGGLE 276_ SPLLL 281_ DSPTS 286_ RTPPP 291_ PSCSS 296_ ASSCS 301_ SSASS 306_ CSSAS 311_ AASTP 316_ SGAPT 321_ CCASA 326_ AAAAA 331_ AALLY 336_ GTGGA 341_ EDLLA 346_ PGAPC 351_ AACSS 356_ ASCAN 361_ NAFAF 366_ GPELS 371_ SLITP 376_ LAIQT 381_ HNFAA 386_ VAAAA 391_ YYRSQ 396_ QQQQQ 401_ QGLAP 406_ PAQPP 411_ APPSA 416_ TLPAG 421_ AAAPP 426_ SPPFS 431_ FQLPR 436_ RLSDS 441_ PVFDA 446_ PPSPP 451_ DSLSD 456_ RDSYL 461_ SGSLS 466_ SGSLS 471_ GSESP 476_ SLDPG 481_ RRLPI 486_FSRLS
1: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:14981510, PubMed:25106868, PubMed:34611029). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:14981510, PubMed:20506496, PubMed:25106868). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA