Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
1_MQQPF 6_ NYPYP 11_ QIYWV 16_ DSSAS 21_ SPWAP 26_ PGTVL 31_ PCPTS 36_ VPRRP 41_ GQRRP 46_ PPPPP 51_ PPPLP 56_ PPPPP 61_ PPLPP 66_ LPLPP 71_ LKKRG 76_ NHSTG 81_ LCLLV 86_ MFFMV 91_ LVALV 96_ GLGLG 101_ MFQLF 106_ HLQKE 111_ LAELR 116_ ESTSQ 121_ MHTAS 126_ SLEKQ 131_ IGHPS 136_ PPPEK 141_ KELRK 146_ VAHLT 151_ GKSNS 156_ RSMPL 161_ EWEDT 166_ YGIVL 171_ LSGVK 176_ YKKGG 181_ LVINE 186_ TGLYF 191_ VYSKV 196_ YFRGQ 201_ SCNNL 206_ PLSHK 211_ VYMRN 216_ SKYPQ 221_ DLVMM 226_ EGKMM 231_ SYCTT 236_ GQMWA 241_ RSSYL 246_ GAVFN 251_ LTSAD 256_ HLYVN 261_ VSELS 266_ LVNFE 271_ ESQTF 276_FGLYK
1: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:7528780, PubMed:9228058, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis also has a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260)
2: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (By similarity). Can induce apoptosis but does not appear to be essential for this process (PubMed:27806260)
3: Cytoplasmic form induces gene transcription inhibition