Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)
1_MQGNG 6_ SALPN 11_ ASQPV 16_ LRGDG 21_ ARPSW 26_ LASAL 31_ ACVLI 36_ FTIVV 41_ DILGN 46_ LLVIL 51_ SVYRN 56_ KKLRN 61_ AGNIF 66_ VVSLA 71_ VADLV 76_ VAIYP 81_ YPLVL 86_ MSIFN 91_ NGWNL 96_ GYLHC 101_ QVSGF 106_ LMGLS 111_ VIGSI 116_ FNITG 121_ IAINR 126_ YCYIC 131_ HSLKY 136_ DKLYS 141_ SKNSL 146_ CYVLL 151_ IWLLT 156_ LAAVL 161_ PNLRA 166_ GTLQY 171_ DPRIY 176_ SCTFA 181_ QSVSS 186_ AYTIA 191_ VVVFH 196_ FLVPM 201_ IIVIF 206_ CYLRI 211_ WILVL 216_ QVRQR 221_ VKPDR 226_ KPKLK 231_ PQDFR 236_ NFVTM 241_ FVVFV 246_ LFAIC 251_ WAPLN 256_ FIGLA 261_ VASDP 266_ ASMVP 271_ RIPEW 276_ LFVAS 281_ YYMAY 286_ FNSCL 291_ NAIIY 296_ GLLNQ 301_ NFRKE 306_ YRRII 311_ VSLCT 316_ ARVFF 321_ VDSSN 326_ DVADR 331_ VKWKP 336_ SPLMT 341_NNNVV
1: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Possibly involved in sleep induction, by melatonin activation of the potassium channel KCNMA1/BK and the dissociation of G-beta and G-gamma subunits, thereby decreasing synaptic transmission (By similarity)