ATP synthase subunit O, mitochondrial (ATP synthase peripheral stalk subunit OSCP) (Oligomycin sensitivity conferral protein) (OSCP)
1_MAAPA 6_ VSGLS 11_ RQVRC 16_ FSTSV 21_ VRPFA 26_ KLVRP 31_ PVQVY 36_ GIEGR 41_ YATAL 46_ YSAAS 51_ KQNKL 56_ EQVEK 61_ ELLRV 66_ AQILK 71_ EPKVA 76_ ASVLN 81_ PYVKR 86_ SIKVK 91_ SLNDI 96_ TAKER 101_ FSPLT 106_ TNLIN 111_ LLAEN 116_ GRLSN 121_ TQGVV 126_ SAFST 131_ MMSVH 136_ RGEVP 141_ CTVTS 146_ ASPLE 151_ EATLS 156_ ELKTV 161_ LKSFL 166_ SQGQV 171_ LKLEA 176_ KTDPS 181_ ILGGM 186_ IVRIG 191_ EKYVD 196_ MSVKT 201_ KIQKL 206_GRAMR
1: Subunit OSCP, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity)