ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1)
1_MNASS 6_ RNVFD 11_ TLIRV 16_ LTESM 21_ FKHLR 26_ KWVVT 31_ RFFGH 36_ SRQRA 41_ RLVSK 46_ DGRCN 51_ IEFGN 56_ VEAQS 61_ RFIFF 66_ VDIWT 71_ TVLDL 76_ KWRYK 81_ MTIFI 86_ TAFLG 91_ SWFFF 96_ GLLWY 101_ AVAYI 106_ HKDLP 111_ EFHPS 116_ ANHTP 121_ CVENI 126_ NGLTS 131_ AFLFS 136_ LETQV 141_ TIGYG 146_ FRCVT 151_ EQCAT 156_ AIFLL 161_ IFQSI 166_ LGVII 171_ NSFMC 176_ GAILA 181_ KISRP 186_ KKRAK 191_ TITFS 196_ KNAVI 201_ SKRGG 206_ KLCLL 211_ IRVAN 216_ LRKSL 221_ LIGSH 226_ IYGKL 231_ LKTTV 236_ TPEGE 241_ TIILD 246_ QININ 251_ FVVDA 256_ GNENL 261_ FFISP 266_ LTIYH 271_ VIDHN 276_ SPFFH 281_ MAAET 286_ LLQQD 291_ FELVV 296_ FLDGT 301_ VESTS 306_ ATCQV 311_ RTSYV 316_ PEEVL 321_ WGYRF 326_ APIVS 331_ KTKEG 336_ KYRVD 341_ FHNFS 346_ KTVEV 351_ ETPHC 356_ AMCLY 361_ NEKDV 366_ RARMK 371_ RGYDN 376_ PNFIL 381_ SEVNE 386_TDDTK
1: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis