Inward rectifier potassium channel 4 (HIRK2) (HRK1) (Hippocampal inward rectifier) (HIR) (Inward rectifier K(+) channel Kir2.3) (IRK-3) (Potassium channel, inwardly rectifying subfamily J member 4)
1_MHGHS 6_ RNGQA 11_ HVPRR 16_ KRRNR 21_ FVKKN 26_ GQCNV 31_ YFANL 36_ SNKSQ 41_ RYMAD 46_ IFTTC 51_ VDTRW 56_ RYMLM 61_ IFSAA 66_ FLVSW 71_ LFFGL 76_ LFWCI 81_ AFFHG 86_ DLEAS 91_ PGVPA 96_ AGGPA 101_ AGGGG 106_ AAPVA 111_ PKPCI 116_ MHVNG 121_ FLGAF 126_ LFSVE 131_ TQTTI 136_ GYGFR 141_ CVTEE 146_ CPLAV 151_ IAVVV 156_ QSIVG 161_ CVIDS 166_ FMIGT 171_ IMAKM 176_ ARPKK 181_ RAQTL 186_ LFSHH 191_ AVISV 196_ RDGKL 201_ CLMWR 206_ VGNLR 211_ KSHIV 216_ EAHVR 221_ AQLIK 226_ PYMTQ 231_ EGEYL 236_ PLDQR 241_ DLNVG 246_ YDIGL 251_ DRIFL 256_ VSPII 261_ IVHEI 266_ DEDSP 271_ LYGMG 276_ KEELE 281_ SEDFE 286_ IVVIL 291_ EGMVE 296_ ATAMT 301_ TQARS 306_ SYLAS 311_ EILWG 316_ HRFEP 321_ VVFEE 326_ KSHYK 331_ VDYSR 336_ FHKTY 341_ EVAGT 346_ PCCSA 351_ RELQE 356_ SKITV 361_ LPAPP 366_ PPPSA 371_ FCYEN 376_ ELALM 381_ SQEEE 386_ EMEEE 391_ AAAAA 396_ AVAAG 401_ LGLEA 406_ GSKEE 411_ AGIIR 416_ MLEFG 421_ SHLDL 426_ ERMQA 431_ SLPLD 436_NISYR
1: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium