G protein-activated inward rectifier potassium channel 2 (GIRK-2) (BIR1) (Inward rectifier K(+) channel Kir3.2) (KATP-2) (Potassium channel, inwardly rectifying subfamily J member 6)
1_MAKLT 6_ ESMTN 11_ VLEGD 16_ SMDQD 21_ VESPV 26_ AIHQP 31_ KLPKQ 36_ ARDDL 41_ PRHIS 46_ RDRTK 51_ RKIQR 56_ YVRKD 61_ GKCNV 66_ HHGNV 71_ RETYR 76_ YLTDI 81_ FTTLV 86_ DLKWR 91_ FNLLI 96_ FVMVY 101_ TVTWL 106_ FFGMI 111_ WWLIA 116_ YIRGD 121_ MDHIE 126_ DPSWT 131_ PCVTN 136_ LNGFV 141_ SAFLF 146_ SIETE 151_ TTIGY 156_ GYRVI 161_ TDKCP 166_ EGIIL 171_ LLIQS 176_ VLGSI 181_ VNAFM 186_ VGCMF 191_ VKISQ 196_ PKKRA 201_ ETLVF 206_ STHAV 211_ ISMRD 216_ GKLCL 221_ MFRVG 226_ DLRNS 231_ HIVEA 236_ SIRAK 241_ LIKSK 246_ QTSEG 251_ EFIPL 256_ NQTDI 261_ NVGYY 266_ TGDDR 271_ LFLVS 276_ PLIIS 281_ HEINQ 286_ QSPFW 291_ EISKA 296_ QLPKE 301_ ELEIV 306_ VILEG 311_ MVEAT 316_ GMTCQ 321_ ARSSY 326_ ITSEI 331_ LWGYR 336_ FTPVL 341_ TLEDG 346_ FYEVD 351_ YNSFH 356_ ETYET 361_ STPSL 366_ SAKEL 371_ AELAS 376_ RAELP 381_ LSWSV 386_ SSKLN 391_ QHAEL 396_ ETEEE 401_ EKNLE 406_ EQTER 411_ NGDVA 416_NLENE
1: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors