Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4)
1_MRIIS 6_ RQIVL 11_ LFSGF 16_ WGLAM 21_ GAFPS 26_ SVQIG 31_ GLFIR 36_ NTDQE 41_ YTAFR 46_ LAIFL 51_ HNTSP 56_ NASEA 61_ PFNLV 66_ PHVDN 71_ IETAN 76_ SFAVT 81_ NAFCS 86_ QYSRG 91_ VFAIF 96_ GLYDK 101_ RSVHT 106_ LTSFC 111_ SALHI 116_ SLITP 121_ SFPTE 126_ GESQF 131_ VLQLR 136_ PSLRG 141_ ALLSL 146_ LDHYE 151_ WNCFV 156_ FLYDT 161_ DRGYS 166_ ILQAI 171_ MEKAG 176_ QNGWH 181_ VSAIC 186_ VENFN 191_ DVSYR 196_ QLLEE 201_ LDRRQ 206_ EKKFV 211_ IDCEI 216_ ERLQN 221_ ILEQI 226_ VSVGK 231_ HVKGY 236_ HYIIA 241_ NLGFK 246_ DISLE 251_ RFIHG 256_ GANVT 261_ GFQLV 266_ DFNTP 271_ MVIKL 276_ MDRWK 281_ KLDQR 286_ EYPGS 291_ ETPPK 296_ YTSAL 301_ TYDGV 306_ LVMAE 311_ TFRSL 316_ RRQKI 321_ DISRR 326_ GNAGD 331_ CLANP 336_ AAPWG 341_ QGIDM 346_ ERTLK 351_ QVRIQ 356_ GLTGN 361_ VQFDH 366_ YGRRV 371_ NYTMD 376_ VFELK 381_ STGPR 386_ KVGYW 391_ NDMDK 396_ LVLIQ 401_ DVPTL 406_ GNDTA 411_ AIENR 416_ TVVVT 421_ TIMES 426_ PYVMY 431_ KKNHE 436_ MFEGN 441_ DKYEG 446_ YCVDL 451_ ASEIA 456_ KHIGI 461_ KYKIA 466_ IVPDG 471_ KYGAR 476_ DADTK 481_ IWNGM 486_ VGELV 491_ YGKAE 496_ IAIAP 501_ LTITL 506_ VREEV 511_ IDFSK 516_ PFMSL 521_ GISIM 526_ IKKPQ 531_ KSKPG 536_ VFSFL 541_ DPLAY 546_ EIWMC 551_ IVFAY 556_ IGVSV 561_ VLFLV 566_ SRFSP 571_ YEWHT 576_ EEPED 581_ GKEGP 586_ SDQPP 591_ NEFGI 596_ FNSLW 601_ FSLGA 606_ FMQQG 611_ CDISP 616_ RSLSG 621_ RIVGG 626_ VWWFF 631_ TLIII 636_ SSYTA 641_ NLAAF 646_ LTVER 651_ MVSPI 656_ ESAED 661_ LAKQT 666_ EIAYG 671_ TLDSG 676_ STKEF 681_ FRRSK 686_ IAVYE 691_ KMWTY 696_ MRSAE 701_ PSVFT 706_ RTTAE 711_ GVARV 716_ RKSKG 721_ KFAFL 726_ LESTM 731_ NEYIE 736_ QRKPC 741_ DTMKV 746_ GGNLD 751_ SKGYG 756_ VATPK 761_ GSSLR 766_ TPVNL 771_ AVLKL 776_ SEAGV 781_ LDKLK 786_ NKWWY 791_ DKGEC 796_ GPKDS 801_ GSKDK 806_ TSALS 811_ LSNVA 816_ GVFYI 821_ LVGGL 826_ GLAML 831_ VALIE 836_ FCYKS 841_ RAEAK 846_ RMKLT 851_ FSEAI 856_ RNKAR 861_ LSITG 866_ SVGEN 871_ GRVLT 876_ PDCPK 881_ AVHTG 886_ TAIRQ 891_ SSGLA 896_VIASD
1: Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (PubMed:21172611)