LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48)
1_MANAL 6_ ASATC 11_ ERCKG 16_ GFAPA 21_ EKIVN 26_ SNGEL 31_ YHEQC 36_ FVCAQ 41_ CFQQF 46_ PEGLF 51_ YEFEG 56_ RKYCE 61_ HDFQM 66_ LFAPC 71_ CHQCG 76_ EFIIG 81_ RVIKA 86_ MNNSW 91_ HPECF 96_ RCDLC 101_ QEVLA 106_ DIGFV 111_ KNAGR 116_ HLCRP 121_ CHNRE 126_ KARGL 131_ GKYIC 136_ QKCHA 141_ IIDEQ 146_ PLIFK 151_ NDPYH 156_ PDHFN 161_ CANCG 166_ KELTA 171_ DAREL 176_ KGELY 181_ CLPCH 186_ DKMGV 191_ PICGA 196_ CRRPI 201_ EGRVV 206_ NAMGK 211_ QWHVE 216_ HFVCA 221_ KCEKP 226_ FLGHR 231_ HYERK 236_ GLAYC 241_ ETHYN 246_ QLFGD 251_ VCFHC 256_ NRVIE 261_ GDVVS 266_ ALNKA 271_ WCVNC 276_ FACST 281_ CNTKL 286_ TLKNK 291_ FVEFD 296_ MKPVC 301_ KKCYE 306_ KFPLE 311_ LKKRL 316_KKLAE
1: Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration