Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4)
1_MVSAK 6_ KVPAI 11_ ALSAG 16_ VSFAL 21_ LRFLC 26_ LAVCL 31_ NESPG 36_ QNQKE 41_ EKLCT 46_ ENFTR 51_ ILDSL 56_ LDGYD 61_ NRLRP 66_ GFGGP 71_ VTEVK 76_ TDIYV 81_ TSFGP 86_ VSDVE 91_ MEYTM 96_ DVFFR 101_ QTWID 106_ KRLKY 111_ DGPIE 116_ ILRLN 121_ NMMVT 126_ KVWTP 131_ DTFFR 136_ NGKKS 141_ VSHNM 146_ TAPNK 151_ LFRIM 156_ RNGTI 161_ LYTMR 166_ LTISA 171_ ECPMR 176_ LVDFP 181_ MDGHA 186_ CPLKF 191_ GSYAY 196_ PKSEM 201_ IYTWT 206_ KGPEK 211_ SVEVP 216_ KESSS 221_ LVQYD 226_ LIGQT 231_ VSSET 236_ IKSIT 241_ GEYIV 246_ MTVYF 251_ HLRRK 256_ MGYFM 261_ IQTYI 266_ PCIMT 271_ VILSQ 276_ VSFWI 281_ NKESV 286_ PARTV 291_ FGITT 296_ VLTMT 301_ TLSIS 306_ ARHSL 311_ PKVSY 316_ ATAMD 321_ WFIAV 326_ CFAFV 331_ FSALI 336_ EFAAV 341_ NYFTN 346_ IQMEK 351_ AKRKT 356_ SKPPQ 361_ EVPAA 366_ PVQRE 371_ KHPEA 376_ PLQNT 381_ NANLN 386_ MRKRT 391_ NALVH 396_ SESDV 401_ GNRTE 406_ VGNHS 411_ SKSST 416_ VVQES 421_ SKGTP 426_ RSYLA 431_ SSPNP 436_ FSRAN 441_ AAETI 446_ SAARA 451_ LPSAS 456_ PTSIR 461_ TGYMP 466_ RKASV 471_ GSAST 476_ RHVFG 481_ SRLQR 486_ IKTTV 491_ NTIGA 496_ TGKLS 501_ ATPPP 506_ SAPPP 511_ SGSGT 516_ SKIDK 521_ YARIL 526_ FPVTF 531_ GAFNM 536_ VYWVV 541_ YLSKD 546_TMEKS
1: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:35355020). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:35355020). GABAARs containing alpha-4 are predominantly extrasynaptic, contributing to tonic inhibition in dentate granule cells and thalamic relay neurons (By similarity). Extrasynaptic alpha-4-containing GABAARs control levels of excitability and network activity (By similarity). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (PubMed:35355020)