Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2)
1_MDAPK 6_ AGYAF 11_ EYLIE 16_ TLNDS 21_ SHKKF 26_ FDVSK 31_ LGTKY 36_ DVLPY 41_ SIRVL 46_ LEAAV 51_ RNCDG 56_ FLMKK 61_ EDVMN 66_ ILDWK 71_ TKQSN 76_ VEVPF 81_ FPARV 86_ LLQDF 91_ TGIPA 96_ MVDFA 101_ AMREA 106_ VKTLG 111_ GDPEK 116_ VHPAC 121_ PTDLT 126_ VDHSL 131_ QIDFS 136_ KCAIQ 141_ NAPNP 146_ GGGDL 151_ QKAGK 156_ LSPLK 161_ VQPKK 166_ LPCRG 171_ QTTCR 176_ GSCDS 181_ GELGR 186_ NSGTF 191_ SSQIE 196_ NTPIL 201_ CPFHL 206_ QPVPE 211_ PETVL 216_ KNQEV 221_ EFGRN 226_ RERLQ 231_ FFKWS 236_ SRVFK 241_ NVAVI 246_ PPGTG 251_ MAHQI 256_ NLEYL 261_ SRVVF 266_ EEKDL 271_ LFPDS 276_ VVGTD 281_ SHITM 286_ VNGLG 291_ ILGWG 296_ VGGIE 301_ TEAVM 306_ LGLPV 311_ SLTLP 316_ EVVGC 321_ ELTGS 326_ SNPFV 331_ TSIDV 336_ VLGIT 341_ KHLRQ 346_ VGVAG 351_ KFVEF 356_ FGSGV 361_ SQLSI 366_ VDRTT 371_ IANMC 376_ PEYGA 381_ ILSFF 386_ PVDNV 391_ TLKHL 396_ EHTGF 401_ SKAKL 406_ ESMET 411_ YLKAV 416_ KLFRN 421_ DQNSS 426_ GEPEY 431_ SQVIQ 436_ INLNS 441_ IVPSV 446_ SGPKR 451_ PQDRV 456_ AVTDM 461_ KSDFQ 466_ ACLNE 471_ KVGFK 476_ GFQIA 481_ AEKQK 486_ DIVSI 491_ HYEGS 496_ EYKLS 501_ HGSVV 506_ IAAVI 511_ SCTNN 516_ CNPSV 521_ MLAAG 526_ LLAKK 531_ AVEAG 536_ LRVKP 541_ YIRTS 546_ LSPGS 551_ GMVTH 556_ YLSSS 561_ GVLPY 566_ LSKLG 571_ FEIVG 576_ YGCSI 581_ CVGNT 586_ APLSD 591_ AVLNA 596_ VKQGD 601_ LVTCG 606_ ILSGN 611_ KNFEG 616_ RLCDC 621_ VRANY 626_ LASPP 631_ LVVAY 636_ AIAGT 641_ VNIDF 646_ QTEPL 651_ GTDPT 656_ GKNIY 661_ LHDIW 666_ PSREE 671_ VHRVE 676_ EEHVI 681_ LSMFK 686_ ALKDK 691_ IEMGN 696_ KRWNS 701_ LEAPD 706_ SVLFP 711_ WDLKS 716_ TYIRC 721_ PSFFD 726_ KLTKE 731_ PIALQ 736_ AIENA 741_ HVLLY 746_ LGDSV 751_ TTDHI 756_ SPAGS 761_ IARNS 766_ AAAKY 771_ LTNRG 776_ LTPRE 781_ FNSYG 786_ ARRGN 791_ DAVMT 796_ RGTFA 801_ NIKLF 806_ NKFIG 811_ KPAPK 816_ TIHFP 821_ SGQTL 826_ DVFEA 831_ AELYQ 836_ KEGIP 841_ LIILA 846_ GKKYG 851_ SGNSR 856_ DWAAK 861_ GPYLL 866_ GVKAV 871_ LAESY 876_ EKIHK 881_ DHLIG 886_ IGIAP 891_ LQFLP 896_ GENAD 901_ SLGLS 906_ GRETF 911_ SLTFP 916_ EELSP 921_ GITLN 926_ IQTST 931_ GKVFS 936_ VIASF 941_ EDDVE 946_ ITLYK 951_ HGGLL 956_NFVAR
1: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA