Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295)
1_MICQK 6_ FCVVL 11_ LHWEF 16_ IYVIT 21_ AFNLS 26_ YPITP 31_ WRFKL 36_ SCMPP 41_ NSTYD 46_ YFLLP 51_ AGLSK 56_ NTSNS 61_ NGHYE 66_ TAVEP 71_ KFNSS 76_ GTHFS 81_ NLSKT 86_ TFHCC 91_ FRSEQ 96_ DRNCS 101_ LCADN 106_ IEGKT 111_ FVSTV 116_ NSLVF 121_ QQIDA 126_ NWNIQ 131_ CWLKG 136_ DLKLF 141_ ICYVE 146_ SLFKN 151_ LFRNY 156_ NYKVH 161_ LLYVL 166_ PEVLE 171_ DSPLV 176_ PQKGS 181_ FQMVH 186_ CNCSV 191_ HECCE 196_ CLVPV 201_ PTAKL 206_ NDTLL 211_ MCLKI 216_ TSGGV 221_ IFQSP 226_ LMSVQ 231_ PINMV 236_ KPDPP 241_ LGLHM 246_ EITDD 251_ GNLKI 256_ SWSSP 261_ PLVPF 266_ PLQYQ 271_ VKYSE 276_ NSTTV 281_ IREAD 286_ KIVSA 291_ TSLLV 296_ DSILP 301_ GSSYE 306_ VQVRG 311_ KRLDG 316_ PGIWS 321_ DWSTP 326_ RVFTT 331_ QDVIY 336_ FPPKI 341_ LTSVG 346_ SNVSF 351_ HCIYK 356_ KENKI 361_ VPSKE 366_ IVWWM 371_ NLAEK 376_ IPQSQ 381_ YDVVS 386_ DHVSK 391_ VTFFN 396_ LNETK 401_ PRGKF 406_ TYDAV 411_ YCCNE 416_ HECHH 421_ RYAEL 426_ YVIDV 431_ NINIS 436_ CETDG 441_ YLTKM 446_ TCRWS 451_ TSTIQ 456_ SLAES 461_ TLQLR 466_ YHRSS 471_ LYCSD 476_ IPSIH 481_ PISEP 486_ KDCYL 491_ QSDGF 496_ YECIF 501_ QPIFL 506_ LSGYT 511_ MWIRI 516_ NHSLG 521_ SLDSP 526_ PTCVL 531_ PDSVV 536_ KPLPP 541_ SSVKA 546_ EITIN 551_ IGLLK 556_ ISWEK 561_ PVFPE 566_ NNLQF 571_ QIRYG 576_ LSGKE 581_ VQWKM 586_ YEVYD 591_ AKSKS 596_ VSLPV 601_ PDLCA 606_ VYAVQ 611_ VRCKR 616_ LDGLG 621_ YWSNW 626_ SNPAY 631_ TVVMD 636_ IKVPM 641_ RGPEF 646_ WRIIN 651_ GDTMK 656_ KEKNV 661_ TLLWK 666_ PLMKN 671_ DSLCS 676_ VQRYV 681_ INHHT 686_ SCNGT 691_ WSEDV 696_ GNHTK 701_ FTFLW 706_ TEQAH 711_ TVTVL 716_ AINSI 721_ GASVA 726_ NFNLT 731_ FSWPM 736_ SKVNI 741_ VQSLS 746_ AYPLN 751_ SSCVI 756_ VSWIL 761_ SPSDY 766_ KLMYF 771_ IIEWK 776_ NLNED 781_ GEIKW 786_ LRISS 791_ SVKKY 796_ YIHDH 801_ FIPIE 806_ KYQFS 811_ LYPIF 816_ MEGVG 821_ KPKII 826_ NSFTQ 831_ DDIEK 836_ HQSDA 841_ GLYVI 846_ VPVII 851_ SSSIL 856_ LLGTL 861_ LISHQ 866_ RMKKL 871_ FWEDV 876_ PNPKN 881_ CSWAQ 886_ GLNFQ 891_ KPETF 896_ EHLFI 901_ KHTAS 906_ VTCGP 911_ LLLEP 916_ ETISE 921_ DISVD 926_ TSWKN 931_ KDEMM 936_ PTTVV 941_ SLLST 946_ TDLEK 951_ GSVCI 956_ SDQFN 961_ SVNFS 966_ EAEGT 971_ EVTYE 976_ DESQR 981_ QPFVK 986_ YATLI 991_ SNSKP 996_ SETGE 1001_ EQGLI 1006_ NSSVT 1011_ KCFSS 1016_ KNSPL 1021_ KDSFS 1026_ NSSWE 1031_ IEAQA 1036_ FFILS 1041_ DQHPN 1046_ IISPH 1051_ LTFSE 1056_ GLDEL 1061_ LKLEG 1066_ NFPEE 1071_ NNDKK 1076_ SIYYL 1081_ GVTSI 1086_ KKRES 1091_ GVLLT 1096_ DKSRV 1101_ SCPFP 1106_ APCLF 1111_ TDIRV 1116_ LQDSC 1121_ SHFVE 1126_ NNINL 1131_ GTSSK 1136_ KTFAS 1141_ YMPQF 1146_ QTCST 1151_ QTHKI 1156_MENKM
1: Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:12504075, PubMed:25060689, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity)
2: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3
3: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis