Transcription factor RFX3 (Regulatory factor X 3)
1_MQTSE 6_ TGSDT 11_ GSTVT 16_ LQTSV 21_ ASQAA 26_ VPTQV 31_ VQQVP 36_ VQQQV 41_ QQVQT 46_ VQQVQ 51_ HVYPA 56_ QVQYV 61_ EGSDT 66_ VYTNG 71_ AIRTT 76_ TYPYT 81_ ETQMY 86_ SQNTG 91_ GNYFD 96_ TQGSS 101_ AQVTT 106_ VVSSH 111_ SMVGT 116_ GGIQM 121_ GVTGG 126_ QLISS 131_ SGGTY 136_ LIGNS 141_ MENSG 146_ HSVTH 151_ TTRAS 156_ PATIE 161_ MAIET 166_ LQKSD 171_ GLSTH 176_ RSSLL 181_ NSHLQ 186_ WLLDN 191_ YETAE 196_ GVSLP 201_ RSTLY 206_ NHYLR 211_ HCQEH 216_ KLDPV 221_ NAASF 226_ GKLIR 231_ SIFMG 236_ LRTRR 241_ LGTRG 246_ NSKYH 251_ YYGIR 256_ VKPDS 261_ PLNRL 266_ QEDMQ 271_ YMAMR 276_ QQPMQ 281_ QKQRY 286_ KPMQK 291_ VDGVA 296_ DGFTG 301_ SGQQT 306_ GTSVE 311_ QTVIA 316_ QSQHH 321_ QQFLD 326_ ASRAL 331_ PEFGE 336_ VEISS 341_ LPDGT 346_ TFEDI 351_ KSLQS 356_ LYREH 361_ CEAIL 366_ DVVVN 371_ LQFSL 376_ IEKLW 381_ QTFWR 386_ YSPST 391_ PTDGT 396_ TITES 401_ SNLSE 406_ IESRL 411_ PKAKL 416_ ITLCK 421_ HESIL 426_ KWMCN 431_ CDHGM 436_ YQALV 441_ EILIP 446_ DVLRP 451_ IPSAL 456_ TQAIR 461_ NFAKS 466_ LEGWL 471_ SNAMN 476_ NIPQR 481_ MIQTK 486_ VAAVS 491_ AFAQT 496_ LRRYT 501_ SLNHL 506_ AQAAR 511_ AVLQN 516_ TSQIN 521_ QMLSD 526_ LNRVD 531_ FANVQ 536_ EQASW 541_ VCQCD 546_ DNMVQ 551_ RLETD 556_ FKMTL 561_ QQQST 566_ LEQWA 571_ AWLDN 576_ VMMQA 581_ LKPYE 586_ GRPSF 591_ PKAAR 596_ QFLLK 601_ WSFYS 606_ SMVIR 611_ DLTLR 616_ SAASF 621_ GSFHL 626_ IRLLY 631_ DEYMF 636_ YLVEH 641_ RVAQA 646_ TGETP 651_ IAVMG 656_ EFGDL 661_ NAVSP 666_ GNLDK 671_ DEGSE 676_ VESEM 681_ DEELD 686_ DSSEP 691_ QAKRE 696_ KTELS 701_ QAFPV 706_ GCMQP 711_ VLETG 716_ VQPSL 721_ LNPIH 726_ SEHIV 731_ TSTQT 736_ IRQCS 741_ATGNT
1: Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (PubMed:12411430)