Transcription factor SOX-2
1_MYNMM 6_ ETELK 11_ PPGPQ 16_ QTSGG 21_ GGGNS 26_ TAAAA 31_ GGNQK 36_ NSPDR 41_ VKRPM 46_ NAFMV 51_ WSRGQ 56_ RRKMA 61_ QENPK 66_ MHNSE 71_ ISKRL 76_ GAEWK 81_ LLSET 86_ EKRPF 91_ IDEAK 96_ RLRAL 101_ HMKEH 106_ PDYKY 111_ RPRRK 116_ TKTLM 121_ KKDKY 126_ TLPGG 131_ LLAPG 136_ GNSMA 141_ SGVGV 146_ GAGLG 151_ AGVNQ 156_ RMDSY 161_ AHMNG 166_ WSNGS 171_ YSMMQ 176_ DQLGY 181_ PQHPG 186_ LNAHG 191_ AAQMQ 196_ PMHRY 201_ DVSAL 206_ QYNSM 211_ TSSQT 216_ YMNGS 221_ PTYSM 226_ SYSQQ 231_ GTPGM 236_ ALGSM 241_ GSVVK 246_ SEASS 251_ SPPVV 256_ TSSSH 261_ SRAPC 266_ QAGDL 271_ RDMIS 276_ MYLPG 281_ AEVPE 286_ PAAPS 291_ RLHMS 296_ QHYQS 301_ GPVPG 306_ TAING 311_TLPLS
1: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity)