Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC) (hOSC)
1_MTEGT 6_ CLRRR 11_ GGPYK 16_ TEPAT 21_ DLGRW 26_ RLNCE 31_ RGRQT 36_ WTYLQ 41_ DERAG 46_ REQTG 51_ LEAYA 56_ LGLDT 61_ KNYFK 66_ DLPKA 71_ HTAFE 76_ GALNG 81_ MTFYV 86_ GLQAE 91_ DGHWT 96_ GDYGG 101_ PLFLL 106_ PGLLI 111_ TCHVA 116_ RIPLP 121_ AGYRE 126_ EIVRY 131_ LRSVQ 136_ LPDGG 141_ WGLHI 146_ EDKST 151_ VFGTA 156_ LNYVS 161_ LRILG 166_ VGPDD 171_ PDLVR 176_ ARNIL 181_ HKKGG 186_ AVAIP 191_ SWGKF 196_ WLAVL 201_ NVYSW 206_ EGLNT 211_ LFPEM 216_ WLFPD 221_ WAPAH 226_ PSTLW 231_ CHCRQ 236_ VYLPM 241_ SYCYA 246_ VRLSA 251_ AEDPL 256_ VQSLR 261_ QELYV 266_ EDFAS 271_ IDWLA 276_ QRNNV 281_ APDEL 286_ YTPHS 291_ WLLRV 296_ VYALL 301_ NLYEH 306_ HHSAH 311_ LRQRA 316_ VQKLY 321_ EHIVA 326_ DDRFT 331_ KSISI 336_ GPISK 341_ TINML 346_ VRWYV 351_ DGPAS 356_ TAFQE 361_ HVSRI 366_ PDYLW 371_ MGLDG 376_ MKMQG 381_ TNGSQ 386_ IWDTA 391_ FAIQA 396_ LLEAG 401_ GHHRP 406_ EFSSC 411_ LQKAH 416_ EFLRL 421_ SQVPD 426_ NPPDY 431_ QKYYR 436_ QMRKG 441_ GFSFS 446_ TLDCG 451_ WIVSD 456_ CTAEA 461_ LKAVL 466_ LLQEK 471_ CPHVT 476_ EHIPR 481_ ERLCD 486_ AVAVL 491_ LNMRN 496_ PDGGF 501_ ATYET 506_ KRGGH 511_ LLELL 516_ NPSEV 521_ FGDIM 526_ IDYTY 531_ VECTS 536_ AVMQA 541_ LKYFH 546_ KRFPE 551_ HRAAE 556_ IRETL 561_ TQGLE 566_ FCRRQ 571_ QRADG 576_ SWEGS 581_ WGVCF 586_ TYGTW 591_ FGLEA 596_ FACMG 601_ QTYRD 606_ GTACA 611_ EVSRA 616_ CDFLL 621_ SRQMA 626_ DGGWG 631_ EDFES 636_ CEERR 641_ YLQSA 646_ QSQIH 651_ NTCWA 656_ MMGLM 661_ AVRHP 666_ DIEAQ 671_ ERGVR 676_ CLLEK 681_ QLPNG 686_ DWPQE 691_ NIAGV 696_ FNKSC 701_ AISYT 706_ SYRNI 711_ FPIWA 716_ LGRFS 721_ QLYPE 726_RALAG
1: Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (PubMed:14766201, PubMed:26200341, PubMed:7639730). Through the production of lanosterol may regulate lens protein aggregation and increase transparency (PubMed:26200341)