CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151)
1_MGEFN 6_ EKKTT 11_ CGTVC 16_ LKYLL 21_ FTYNC 26_ CFWLA 31_ GLAVM 36_ AVGIW 41_ TLALK 46_ SDYIS 51_ LLASG 56_ TYLAT 61_ AYILV 66_ VAGTV 71_ VMVTG 76_ VLGCC 81_ ATFKE 86_ RRNLL 91_ RLYFI 96_ LLLII 101_ FLLEI 106_ IAGIL 111_ AYAYY 116_ QQLNT 121_ ELKEN 126_ LKDTM 131_ TKRYH 136_ QPGHE 141_ AVTSA 146_ VDQLQ 151_ QEFHC 156_ CGSNN 161_ SQDWR 166_ DSEWI 171_ RSQEA 176_ GGRVV 181_ PDSCC 186_ KTVVA 191_ LCGQR 196_ DHASN 201_ IYKVE 206_ GGCIT 211_ KLETF 216_ IQEHL 221_ RVIGA 226_ VGIGI 231_ ACVQV 236_ FGMIF 241_ TCCLY 246_RSLKL
1: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays a role in various cellular and molecular mechanism through its association with both integrin and non-integrin proteins. These interactions facilitate critical cellular functions, including cell-to-cell communication, wound healing, platelet aggregation, trafficking, cell motility, and angiogenesis (PubMed:17045834, PubMed:24723389, PubMed:31488507). Via interaction with JAM-A/F11R and integrin ITGA3:ITGB1, promotes the recruitment of signaling molecules such as RAC1, CDC42 and RhoGTPases to facilitate the polarization of epithelial cells and the reorganization of the actin cytoskeleton, which are critical steps in cell migration process (PubMed:22843693, PubMed:35067832). Regulates the glycosylation pattern of ITGA3:ITGB1 thereby modulating its activity (PubMed:18852263). Plays an essential role in the maintenance of central laminin-binding integrin ITGA6:ITGB4-containing adhesion complexes (PubMed:31488507). Essential for the proper assembly of the glomerular and tubular basement membranes in kidney (PubMed:15265795). Contributes to T-cell activation by modulating integrin signaling leading to activation of downstream targets PTK2 and MAPK1/MAPK3 (PubMed:24723389)
2: (Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor
3: (Microbial infection) Plays a role in human cytomegalovirus entry into host cell by contributing to entry receptor binding, membrane fusion, or release of the capsid