G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (IRK-4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)
1_MAGDS 6_ RNAMN 11_ QDMEI 16_ GVTPW 21_ DPKKI 26_ PKQAR 31_ DYVPI 36_ ATDRT 41_ RLLAE 46_ GKKPR 51_ QRYME 56_ KSGKC 61_ NVHHG 66_ NVQET 71_ YRYLS 76_ DLFTT 81_ LVDLK 86_ WRFNL 91_ LVFTM 96_ VYTVT 101_ WLFFG 106_ FIWWL 111_ IAYIR 116_ GDLDH 121_ VGDQE 126_ WIPCV 131_ ENLSG 136_ FVSAF 141_ LFSIE 146_ TETTI 151_ GYGFR 156_ VITEK 161_ CPEGI 166_ ILLLV 171_ QAILG 176_ SIVNA 181_ FMVGC 186_ MFVKI 191_ SQPKK 196_ RAETL 201_ MFSNN 206_ AVISM 211_ RDEKL 216_ CLMFR 221_ VGDLR 226_ NSHIV 231_ EASIR 236_ AKLIK 241_ SRQTK 246_ EGEFI 251_ PLNQT 256_ DINVG 261_ FDTGD 266_ DRLFL 271_ VSPLI 276_ ISHEI 281_ NQKSP 286_ FWEMS 291_ QAQLH 296_ QEEFE 301_ VVVIL 306_ EGMVE 311_ ATGMT 316_ CQARS 321_ SYMDT 326_ EVLWG 331_ HRFTP 336_ VLTLE 341_ KGFYE 346_ VDYNT 351_ FHDTY 356_ ETNTP 361_ SCCAK 366_ ELAEM 371_ KREGR 376_ LLQYL 381_ PSPPL 386_ LGGCA 391_ EAGLD 396_ AEAEQ 401_ NEEDE 406_ PKGLG 411_GSREA
1: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. This potassium channel is controlled by G proteins