G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3)
1_MSALR 6_ RKFGD 11_ DYQVV 16_ TTSSS 21_ GSGLQ 26_ PQGPG 31_ QDPQQ 36_ QLVPK 41_ KKRQR 46_ FVDKN 51_ GRCNV 56_ QHGNL 61_ GSETS 66_ RYLSD 71_ LFTTL 76_ VDLKW 81_ RWNLF 86_ IFILT 91_ YTVAW 96_ LFMAS 101_ MWWVI 106_ AYTRG 111_ DLNKA 116_ HVGNY 121_ TPCVA 126_ NVYNF 131_ PSAFL 136_ FFIET 141_ EATIG 146_ YGYRY 151_ ITDKC 156_ PEGII 161_ LFLFQ 166_ SILGS 171_ IVDAF 176_ LIGCM 181_ FIKMS 186_ QPKKR 191_ AETLM 196_ FSEHA 201_ VISMR 206_ DGKLT 211_ LMFRV 216_ GNLRN 221_ SHMVS 226_ AQIRC 231_ KLLKS 236_ RQTPE 241_ GEFLP 246_ LDQLE 251_ LDVGF 256_ STGAD 261_ QLFLV 266_ SPLTI 271_ CHVID 276_ AKSPF 281_ YDLSQ 286_ RSMQT 291_ EQFEI 296_ VVILE 301_ GIVET 306_ TGMTC 311_ QARTS 316_ YTEDE 321_ VLWGH 326_ RFFPV 331_ ISLEE 336_ GFFKV 341_ DYSQF 346_ HATFE 351_ VPTPP 356_ YSVKE 361_ QEEML 366_ LMSSP 371_ LIAPA 376_ ITNSK 381_ ERHNS 386_ VECLD 391_ GLDDI 396_ TTKLP 401_ SKLQK 406_ ITGRE 411_ DFPKK 416_ LLRMS 421_ STTSE 426_ KAYSL 431_ GDLPM 436_ KLQRI 441_ SSVPG 446_ NSEEK 451_ LVSKT 456_ TKMLS 461_ DPMSQ 466_ SVADL 471_ PPKLQ 476_ KMAGG 481_ AARME 486_ GNLPA 491_ KLRKM 496_NSDRF
1: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins (PubMed:8804710, PubMed:8868049). This receptor plays a crucial role in regulating the heartbeat (By similarity)