Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2)
1_MLLSQ 6_ NAFIF 11_ RSLNL 16_ VLMVY 21_ ISLVF 26_ GISYD 31_ SPDYT 36_ DESCT 41_ FKISL 46_ RNFRS 51_ ILSWE 56_ LKNHS 61_ IVPTH 66_ YTLLY 71_ TIMSK 76_ PEDLK 81_ VVKNC 86_ ANTTR 91_ SFCDL 96_ TDEWR 101_ STHEA 106_ YVTVL 111_ EGFSG 116_ NTTLF 121_ SCSHN 126_ FWLAI 131_ DMSFE 136_ PPEFE 141_ IVGFT 146_ NHINV 151_ MVKFP 156_ SIVEE 161_ ELQFD 166_ LSLVI 171_ EEQSE 176_ GIVKK 181_ HKPEI 186_ KGNMS 191_ GNFTY 196_ IIDKL 201_ IPNTN 206_ YCVSV 211_ YLEHS 216_ DEQAV 221_ IKSPL 226_ KCTLL 231_ PPGQE 236_ SESAE 241_ SAKIG 246_ GIITV 251_ FLIAL 256_ VLTST 261_ IVTLK 266_ WIGYI 271_ CLRNS 276_ LPKVL 281_ NFHNF 286_ LAWPF 291_ PNLPP 296_ LEAMD 301_ MVEVI 306_ YINRK 311_ KKVWD 316_ YNYDD 321_ ESDSD 326_ TEAAP 331_ RTSGG 336_ GYTMH 341_ GLTVR 346_ PLGQA 351_ SATST 356_ ESQLI 361_ DPESE 366_ EEPDL 371_ PEVDV 376_ ELPTM 381_ PKDSP 386_ QQLEL 391_ LSGPC 396_ ERRKS 401_ PLQDP 406_ FPEED 411_ YSSTE 416_ GSGGR 421_ ITFNV 426_ DLNSV 431_ FLRVL 436_ DDEDS 441_ DDLEA 446_ PLMLS 451_ SHLEE 456_ MVDPE 461_ DPDNV 466_ QSNHL 471_ LASGE 476_ GTQPT 481_ FPSPS 486_ SEGLW 491_ SEDAP 496_ SDQSD 501_ TSESD 506_VDLGD
1: Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:10556041, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995, PubMed:7665574, PubMed:7759950, PubMed:8181059, PubMed:8798579, PubMed:8969169). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (PubMed:10049744, PubMed:17517919, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995, PubMed:7665574, PubMed:7759950, PubMed:8181059, PubMed:8798579, PubMed:8969169). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (PubMed:10556041, PubMed:11682488, PubMed:12105218, PubMed:21854986, PubMed:32972995). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (STAT1, STAT2 and STAT) (PubMed:11682488, PubMed:12105218, PubMed:21854986, PubMed:32972995). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (PubMed:12105218, PubMed:28165510, PubMed:9121453)
2: Potent inhibitor of type I IFN receptor activity