Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase)
1_MATNW 6_ GSLLQ 11_ DKQQL 16_ EELAR 21_ QAVDR 26_ ALAEG 31_ VLLRT 36_ SQEPT 41_ SSEVV 46_ SYAPF 51_ TLFPS 56_ LVPSA 61_ LLEQA 66_ YAVQM 71_ DFNLL 76_ VDAVS 81_ QNAAF 86_ LEQTL 91_ SSTIK 96_ QDDFT 101_ ARLFD 106_ IHKQV 111_ LKEGI 116_ AQTVF 121_ LGLNR 126_ SDYMF 131_ QRSAD 136_ GSPAL 141_ KQIEI 146_ NTISA 151_ SFGGL 156_ ASRTP 161_ AVHRH 166_ VLSVL 171_ SKTKE 176_ AGKIL 181_ SNNPS 186_ KGLAL 191_ GIAKA 196_ WELYG 201_ SPNAL 206_ VLLIA 211_ QEKER 216_ NIFDQ 221_ RAIEN 226_ ELLAR 231_ NIHVI 236_ RRTFE 241_ DISEK 246_ GSLDQ 251_ DRRLF 256_ VDGQE 261_ IAVVY 266_ FRDGY 271_ MPRQY 276_ SLQNW 281_ EARLL 286_ LERSH 291_ AAKCP 296_ DIATQ 301_ LAGTK 306_ KVQQE 311_ LSRPG 316_ MLEML 321_ LPGQP 326_ EAVAR 331_ LRATF 336_ AGLYS 341_ LDVGE 346_ EGDQA 351_ IAEAL 356_ AAPSR 361_ FVLKP 366_ QREGG 371_ GNNLY 376_ GEEMV 381_ QALKQ 386_ LKDSE 391_ ERASY 396_ ILMEK 401_ IEPEP 406_ FENCL 411_ LRPGS 416_ PARVV 421_ QCISE 426_ LGIFG 431_ VYVRQ 436_ EKTLV 441_ MNKHV 446_ GHLLR 451_ TKAIE 456_ HADGG 461_ VAAGV 466_AVLDN
1: Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7646467, PubMed:9215686). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:10369661). Participates in ophthalmate biosynthesis in hepatocytes (By similarity)