Neuromedin-U [Cleaved into: Neuromedin precursor-related peptide 36 (NURP36); Neuromedin precursor-related peptide 33 (NURP33); Neuromedin-U-25 (NmU-25)]
1_MLRTE 6_ SCRPR 11_ SPAGQ 16_ VAAAS 21_ PLLLL 26_ LLLLA 31_ WCAGA 36_ CRGAP 41_ ILPQG 46_ LQPEQ 51_ QLQLW 56_ NEIDD 61_ TCSSF 66_ LSIDS 71_ QPQAS 76_ NALEE 81_ LCFMI 86_ MGMLP 91_ KPQEQ 96_ DEKDN 101_ TKRFL 106_ FHYSK 111_ TQKLG 116_ KSNVV 121_ SSVVH 126_ PLLQL 131_ VPHLH 136_ ERRMK 141_ RFRVD 146_ EEFQS 151_ PFASQ 156_ SRGYF 161_ LFRPR 166_NGRRS
1: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder
2: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36
3: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system