Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6)
1_MSSHG 6_ NSLFL 11_ RESGQ 16_ RLGRV 21_ GWLQR 26_ LQESL 31_ QQRAL 36_ RTRLR 41_ LQTMT 46_ LEHVL 51_ RFLRR 56_ NAFIL 61_ LTVSA 66_ VVIGV 71_ SLAFA 76_ LRPYQ 81_ LTYRQ 86_ IKYFS 91_ FPGEL 96_ LMRML 101_ QMLVL 106_ PLIVS 111_ SLVTG 116_ MASLD 121_ NKATG 126_ RMGMR 131_ AAVYY 136_ MVTTI 141_ IAVFI 146_ GILMV 151_ TIIHP 156_ GKGSK 161_ EGLHR 166_ EGRIE 171_ TIPTA 176_ DAFMD 181_ LIRNM 186_ FPPNL 191_ VEACF 196_ KQFKT 201_ QYSTR 206_ VVTRT 211_ MVRTE 216_ NGSEP 221_ GASMP 226_ PPFSV 231_ ENGTS 236_ FLENV 241_ TRALG 246_ TLQEM 251_ LSFEE 256_ TVPVP 261_ GSANG 266_ INALG 271_ LVVFS 276_ VAFGL 281_ VIGGM 286_ KHKGR 291_ VLRDF 296_ FDSLN 301_ EAIMR 306_ LVGII 311_ IWYAP 316_ VGILF 321_ LIAGK 326_ ILEME 331_ DMAVL 336_ GGQLG 341_ MYTLT 346_ VIVGL 351_ FLHAG 356_ IVLPL 361_ IYFLV 366_ THRNP 371_ FPFIG 376_ GMLQA 381_ LITAM 386_ GTSSS 391_ SATLP 396_ ITFRC 401_ LEEGL 406_ GVDRR 411_ ITRFV 416_ LPVGA 421_ TVNMD 426_ GTALY 431_ EALAA 436_ IFIAQ 441_ VNNYE 446_ LNLGQ 451_ ITTIS 456_ ITATA 461_ ASVGA 466_ AGIPQ 471_ AGLVT 476_ MVIVL 481_ TSVGL 486_ PTEDI 491_ TLIIA 496_ VDWFL 501_ DRLRT 506_ MTNVL 511_ GDSIG 516_ AAVIE 521_ HLSQR 526_ ELELQ 531_ EAELT 536_ LPSLG 541_ KPYKS 546_ LMAQE 551_ KGASR 556_GRGGN
1: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:26690923, PubMed:7791878). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:7791878). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable)