Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1)
1_MASSS 6_ GSKAE 11_ FIVGG 16_ KYKLV 21_ RKIGS 26_ GSFGD 31_ IYLAI 36_ NITNG 41_ EEVAV 46_ KLESQ 51_ KARHP 56_ QLLYE 61_ SKLYK 66_ ILQGG 71_ VGIPH 76_ IRWYG 81_ QEKDY 86_ NVLVM 91_ DLLGP 96_ SLEDL 101_ FNFCS 106_ RRFTM 111_ KTVLM 116_ LADQM 121_ ISRIE 126_ YVHTK 131_ NFIHR 136_ DIKPD 141_ NFLMG 146_ IGRHC 151_ NKLFL 156_ IDFGL 161_ AKKYR 166_ DNRTR 171_ QHIPY 176_ REDKN 181_ LTGTA 186_ RYASI 191_ NAHLG 196_ IEQSR 201_ RDDME 206_ SLGYV 211_ LMYFN 216_ RTSLP 221_ WQGLK 226_ AATKK 231_ QKYEK 236_ ISEKK 241_ MSTPV 246_ EVLCK 251_ GFPAE 256_ FAMYL 261_ NYCRG 266_ LRFEE 271_ APDYM 276_ YLRQL 281_ FRILF 286_ RTLNH 291_ QYDYT 296_ FDWTM 301_ LKQKA 306_ AQQAA 311_ SSSGQ 316_ GQQAQ 321_ TPTGK 326_ QTDKT 331_KSNMK
1: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:11955436, PubMed:1409656, PubMed:18305108, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (PubMed:22017875, PubMed:22017877). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity)