Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
1_MELRV 6_ GNRYR 11_ LGRKI 16_ GSGSF 21_ GDIYL 26_ GTDIA 31_ AGEEV 36_ AIKLE 41_ CVKTK 46_ HPQLH 51_ IESKI 56_ YKMMQ 61_ GGVGI 66_ PTIRW 71_ CGAEG 76_ DYNVM 81_ VMELL 86_ GPSLE 91_ DLFNF 96_ CSRKF 101_ SLKTV 106_ LLLAD 111_ QMISR 116_ IEYIH 121_ SKNFI 126_ HRDVK 131_ PDNFL 136_ MGLGK 141_ KGNLV 146_ YIIDF 151_ GLAKK 156_ YRDAR 161_ THQHI 166_ PYREN 171_ KNLTG 176_ TARYA 181_ SINTH 186_ LGIEQ 191_ SRRDD 196_ LESLG 201_ YVLMY 206_ FNLGS 211_ LPWQG 216_ LKAAT 221_ KRQKY 226_ ERISE 231_ KKMST 236_ PIEVL 241_ CKGYP 246_ SEFAT 251_ YLNFC 256_ RSLRF 261_ DDKPD 266_ YSYLR 271_ QLFRN 276_ LFHRQ 281_ GFSYD 286_ YVFDW 291_ NMLKF 296_ GASRA 301_ ADDAE 306_ RERRD 311_ REERL 316_ RHSRN 321_ PATRG 326_ LPSTA 331_ SGRLR 336_ GTQEV 341_ APPTP 346_ LTPTS 351_ HTANT 356_ SPRPV 361_ SGMER 366_ ERKVS 371_ MRLHR 376_ GAPVN 381_ ISSSD 386_ LTGRQ 391_ DTSRM 396_ STSQI 401_ PGRVA 406_SSGLQ
1: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate