Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)
1_MELEN 6_ YKQPV 11_ VLRED 16_ NCRRR 21_ RRMKP 26_ RSAAA 31_ SLSSM 36_ ELIPI 41_ EFVLP 46_ TSQRK 51_ CKSPE 56_ TALLH 61_ VAGHG 66_ NVEQM 71_ KAQVW 76_ LRALE 81_ TSVAA 86_ DFYHR 91_ LGPHH 96_ FLLLY 101_ QKKGQ 106_ WYEIY 111_ DKYQV 116_ VQTLD 121_ CLRYW 126_ KATHR 131_ SPGQI 136_ HLVQR 141_ HPPSE 146_ ESQAF 151_ QRQLT 156_ ALIGY 161_ DVTDV 166_ SNVHD 171_ DELEF 176_ TRRGL 181_ VTPRM 186_ AEVAS 191_ RDPKL 196_ YAMHP 201_ WVTSK 206_ PLPEY 211_ LWKKI 216_ ANNCI 221_ FIVIH 226_ RSTTS 231_ QTIKV 236_ SPDDT 241_ PGAIL 246_ QSFFT 251_ KMAKK 256_ KSLMD 261_ IPESQ 266_ SEQDF 271_ VLRVC 276_ GRDEY 281_ LVGET 286_ PIKNF 291_ QWVRH 296_ CLKNG 301_ EEIHV 306_ VLDTP 311_ PDPAL 316_ DEVRK 321_ EEWPL 326_ VDDCT 331_ GVTGY 336_ HEQLT 341_ IHGKD 346_ HESVF 351_ TVSLW 356_ DCDRK 361_ FRVKI 366_ RGIDI 371_ PVLPR 376_ NTDLT 381_ VFVEA 386_ NIQHG 391_ QQVLC 396_ QRRTS 401_ PKPFT 406_ EEVLW 411_ NVWLE 416_ FSIKI 421_ KDLPK 426_ GALLN 431_ LQIYC 436_ GKAPA 441_ LSSKA 446_ SAESP 451_ SSESK 456_ GKVQL 461_ LYYVN 466_ LLLID 471_ HRFLL 476_ RRGEY 481_ VLHMW 486_ QISGK 491_ GEDQG 496_ SFNAD 501_ KLTSA 506_ TNPDK 511_ ENSMS 516_ ISILL 521_ DNYCH 526_ PIALP 531_ KHQPT 536_ PDPEG 541_ DRVRA 546_ EMPNQ 551_ LRKQL 556_ EAIIA 561_ TDPLN 566_ PLTAE 571_ DKELL 576_ WHFRY 581_ ESLKH 586_ PKAYP 591_ KLFSS 596_ VKWGQ 601_ QEIVA 606_ KTYQL 611_ LARRE 616_ VWDQS 621_ ALDVG 626_ LTMQL 631_ LDCNF 636_ SDENV 641_ RAIAV 646_ QKLES 651_ LEDDD 656_ VLHYL 661_ LQLVQ 666_ AVKFE 671_ PYHDS 676_ ALARF 681_ LLKRG 686_ LRNKR 691_ IGHFL 696_ FWFLR 701_ SEIAQ 706_ SRHYQ 711_ QRFAV 716_ ILEAY 721_ LRGCG 726_ TAMLH 731_ DFTQQ 736_ VQVIE 741_ MLQKV 746_ TLDIK 751_ SLSAE 756_ KYDVS 761_ SQVIS 766_ QLKQK 771_ LENLQ 776_ NSQLP 781_ ESFRV 786_ PYDPG 791_ LKAGA 796_ LAIEK 801_ CKVMA 806_ SKKKP 811_ LWLEF 816_ KCADP 821_ TALSN 826_ ETIGI 831_ IFKHG 836_ DDLRQ 841_ DMLIL 846_ QILRI 851_ MESIW 856_ ETESL 861_ DLCLL 866_ PYGCI 871_ STGDK 876_ IGMIE 881_ IVKDA 886_ TTIAK 891_ IQQST 896_ VGNTG 901_ AFKDE 906_ VLNHW 911_ LKEKS 916_ PTEEK 921_ FQAAV 926_ ERFVY 931_ SCAGY 936_ CVATF 941_ VLGIG 946_ DRHND 951_ NIMIT 956_ ETGNL 961_ FHIDF 966_ GHILG 971_ NYKSF 976_ LGINK 981_ ERVPF 986_ VLTPD 991_ FLFVM 996_ GTSGK 1001_ KTSPH 1006_ FQKFQ 1011_ DICVK 1016_ AYLAL 1021_ RHHTN 1026_ LLIIL 1031_ FSMML 1036_ MTGMP 1041_ QLTSK 1046_ EDIEY 1051_ IRDAL 1056_ TVGKN 1061_ EEDAK 1066_ KYFLD 1071_ QIEVC 1076_ RDKGW 1081_ TVQFN 1086_ WFLHL 1091_ VLGIK 1096_QGEKH
1: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation, activation, and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway downstream of RASGRP4-mediated Ras-activation, to promote neutrophil functional responses (By similarity)