Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
1_MRWLL 6_ LYYAL 11_ CFSLS 16_ KASAH 21_ TVELN 26_ NMFGQ 31_ IQSPG 36_ YPDSY 41_ PSDSE 46_ VTWNI 51_ TVPDG 56_ FRIKL 61_ YFMHF 66_ NLESS 71_ YLCEY 76_ DYVKV 81_ ETEDQ 86_ VLATF 91_ CGRET 96_ TDTEQ 101_ TPGQE 106_ VVLSP 111_ GSFMS 116_ ITFRS 121_ DFSNE 126_ ERFTG 131_ FDAHY 136_ MAVDV 141_ DECKE 146_ REDEE 151_ LSCDH 156_ YCHNY 161_ IGGYY 166_ CSCRF 171_ GYILH 176_ TDNRT 181_ CRVEC 186_ SDNLF 191_ TQRTG 196_ VITSP 201_ DFPNP 206_ YPKSS 211_ ECLYT 216_ IELEE 221_ GFMVN 226_ LQFED 231_ IFDIE 236_ DHPEV 241_ PCPYD 246_ YIKIK 251_ VGPKV 256_ LGPFC 261_ GEKAP 266_ EPIST 271_ QSHSV 276_ LILFH 281_ SDNSG 286_ ENRGW 291_ RLSYR 296_ AAGNE 301_ CPELQ 306_ PPVHG 311_ KIEPS 316_ QAKYF 321_ FKDQV 326_ LVSCD 331_ TGYKV 336_ LKDNV 341_ EMDTF 346_ QIECL 351_ KDGTW 356_ SNKIP 361_ TCKIV 366_ DCRAP 371_ GELEH 376_ GLITF 381_ STRNN 386_ LTTYK 391_ SEIKY 396_ SCQEP 401_ YYKML 406_ NNNTG 411_ IYTCS 416_ AQGVW 421_ MNKVL 426_ GRSLP 431_ TCLPV 436_ CGLPK 441_ FSRKL 446_ MARIF 451_ NGRPA 456_ QKGTT 461_ PWIAM 466_ LSHLN 471_ GQPFC 476_ GGSLL 481_ GSSWI 486_ VTAAH 491_ CLHQS 496_ LDPED 501_ PTLRD 506_ SDLLS 511_ PSDFK 516_ IILGK 521_ HWRLR 526_ SDENE 531_ QHLGV 536_ KHTTL 541_ HPQYD 546_ PNTFE 551_ NDVAL 556_ VELLE 561_ SPVLN 566_ AFVMP 571_ ICLPE 576_ GPQQE 581_ GAMVI 586_ VSGWG 591_ KQFLQ 596_ RFPET 601_ LMEIE 606_ IPIVD 611_ HSTCQ 616_ KAYAP 621_ LKKKV 626_ TRDMI 631_ CAGEK 636_ EGGKD 641_ ACAGD 646_ SGGPM 651_ VTLNR 656_ ERGQW 661_ YLVGT 666_ VSWGD 671_ DCGKK 676_ DRYGV 681_ YSYIH 686_ HNKDW 691_IQRVT
1: Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed:21258343)