CCN family member 3 (Cellular communication network factor 3) (Insulin-like growth factor-binding protein 9) (IBP-9) (IGF-binding protein 9) (IGFBP-9) (Nephro blastoma-overexpressed gene protein homolog) (Protein NOV homolog) (NovH)
1_MQSVQ 6_ STSFC 11_ LRKQC 16_ LCLTF 21_ LLLHL 26_ LGQVA 31_ ATQRC 36_ PPQCP 41_ GRCPA 46_ TPPTC 51_ APGVR 56_ AVLDG 61_ CSCCL 66_ VCARQ 71_ RGESC 76_ SDLEP 81_ CDESS 86_ GLYCD 91_ RSADP 96_ SNQTG 101_ ICTAV 106_ EGDNC 111_ VFDGV 116_ IYRSG 121_ EKFQP 126_ SCKFQ 131_ CTCRD 136_ GQIGC 141_ VPRCQ 146_ LDVLL 151_ PEPNC 156_ PAPRK 161_ VEVPG 166_ ECCEK 171_ WICGP 176_ DEEDS 181_ LGGLT 186_ LAAYR 191_ PEATL 196_ GVEVS 201_ DSSVN 206_ CIEQT 211_ TEWTA 216_ CSKSC 221_ GMGFS 226_ TRVTN 231_ RNRQC 236_ EMLKQ 241_ TRLCM 246_ VRPCE 251_ QEPEQ 256_ PTDKK 261_ GKKCL 266_ RTKKS 271_ LKAIH 276_ LQFKN 281_ CTSLH 286_ TYKPR 291_ FCGVC 296_ SDGRC 301_ CTPHN 306_ TKTIQ 311_ AEFQC 316_ SPGQI 321_ VKKPV 326_ MVIGT 331_ CTCHT 336_ NCPKN 341_ NEAFL 346_ QELEL 351_KTTRG
1: Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:12050162, PubMed:12695522, PubMed:15181016, PubMed:15611078, PubMed:21344378). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:15611078, PubMed:21344378). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891). Brain osteoanabolic hormone (By similarity). Drives osteogenesis in osteochondral skeletal stem cells (PubMed:38987585). During lactation, maintains the maternal skeleton and viability of offspring (By similarity)