Gene name: TDO2

Uniprot entry:

P48775

Protein names:

Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)

Protein sequence:

1_MSGCP 6_ FLGNN 11_ FGYTF 16_ KKLPV 21_ EGSEE 26_ DKSQT 31_ GVNRA 36_ SKGGL 41_ IYGNY 46_ LHLEK 51_ VLNAQ 56_ ELQSE 61_ TKGNK 66_ IHDEH 71_ LFIIT 76_ HQAYE 81_ LWFKQ 86_ ILWEL 91_ DSVRE 96_ IFQNG 101_ HVRDE 106_ RNMLK 111_ VVSRM 116_ HRVSV 121_ ILKLL 126_ VQQFS 131_ ILETM 136_ TALDF 141_ NDFRE 146_ YLSPA 151_ SGFQS 156_ LQFRL 161_ LENKI 166_ GVLQN 171_ MRVPY 176_ NRRHY 181_ RDNFK 186_ GEENE 191_ LLLKS 196_ EQEKT 201_ LLELV 206_ EAWLE 211_ RTPGL 216_ EPHGF 221_ NFWGK 226_ LEKNI 231_ TRGLE 236_ EEFIR 241_ IQAKE 246_ ESEEK 251_ EEQVA 256_ EFQKQ 261_ KEVLL 266_ SLFDE 271_ KRHEH 276_ LLSKG 281_ ERRLS 286_ YRALQ 291_ GALMI 296_ YFYRE 301_ EPRFQ 306_ VPFQL 311_ LTSLM 316_ DIDSL 321_ MTKWR 326_ YNHVC 331_ MVHRM 336_ LGSKA 341_ GTGGS 346_ SGYHY 351_ LRSTV 356_ SDRYK 361_ VFVDL 366_ FNLST 371_ YLIPR 376_ HWIPK 381_ MNPTI 386_ HKFLY 391_ TAEYC 396_ DSSYF 401_SSDES

Protein annotations

Protein functions:

1: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety