Guided entry of tail-anchored proteins factor CAMLG (Calcium signal-modulating cyclophilin ligand)
1_MESMA 6_ VATDG 11_ GERPG 16_ VPAGS 21_ GLSAS 26_ QRRAE 31_ LRRRK 36_ LLMNS 41_ EQRIN 46_ RIMGF 51_ HRPGS 56_ GAEEE 61_ SQTKS 66_ KQQDS 71_ DKLNS 76_ LSVPS 81_ VSKRV 86_ VLGDS 91_ VSTGT 96_ TDQQG 101_ GVAEV 106_ KGTQL 111_ GDKLD 116_ SFIKP 121_ PECSS 126_ DVNLE 131_ LRQRN 136_ RGDLT 141_ ADSVQ 146_ RGSRH 151_ GLEQY 156_ LSRFE 161_ EAMKL 166_ RKQLI 171_ SEKPS 176_ QEDGN 181_ TTEEF 186_ DSFRI 191_ FRLVG 196_ CALLA 201_ LGVRA 206_ FVCKY 211_ LSIFA 216_ PFLTL 221_ QLAYM 226_ GLYKY 231_ FPKSE 236_ KKIKT 241_ TVLTA 246_ ALLLS 251_ GIPAE 256_ VINRS 261_ MDTYS 266_ KMGEV 271_ FTDLC 276_ VYFFT 281_ FIFCH 286_ ELLDY 291_WGSEV
1: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed:23041287, PubMed:24392163, PubMed:27226539). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:23041287, PubMed:24392163, PubMed:27226539). Required for the stability of GET1 (PubMed:32187542). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed:7522304). Essential for the survival of peripheral follicular B cells (By similarity)