Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)
1_MTSPS 6_ PRIQI 11_ ISTDS 16_ AVASP 21_ QRIQI 26_ VTDQQ 31_ TGQKI 36_ QIVTA 41_ VDASG 46_ SPKQQ 51_ FILTS 56_ PDGAG 61_ TGKVI 66_ LASPE 71_ TSSAK 76_ QLIFT 81_ TSDNL 86_ VPGRI 91_ QIVTD 96_ SASVE 101_ RLLGK 106_ TDVQR 111_ PQVVE 116_ YCVVC 121_ GDKAS 126_ GRHYG 131_ AVSCE 136_ GCKGF 141_ FKRSV 146_ RKNLT 151_ YSCRS 156_ NQDCI 161_ INKHH 166_ RNRCQ 171_ FCRLK 176_ KCLEM 181_ GMKME 186_ SVQSE 191_ RKPFD 196_ VQREK 201_ PSNCA 206_ ASTEK 211_ IYIRK 216_ DLRSP 221_ LIATP 226_ TFVAD 231_ KDGAR 236_ QTGLL 241_ DPGML 246_ VNIQQ 251_ PLIRE 256_ DGTVL 261_ LATDS 266_ KAETS 271_ QGALG 276_ TLANV 281_ VTSLA 286_ NLSES 291_ LNNGD 296_ TSEIQ 301_ PEDQS 306_ ASEIT 311_ RAFDT 316_ LAKAL 321_ NTTDS 326_ SSSPS 331_ LADGI 336_ DTSGG 341_ GSIHV 346_ ISRDQ 351_ STPII 356_ EVEGP 361_ LLSDT 366_ HVTFK 371_ LTMPS 376_ PMPEY 381_ LNVHY 386_ ICESA 391_ SRLLF 396_ LSMHW 401_ ARSIP 406_ AFQAL 411_ GQDCN 416_ TSLVR 421_ ACWNE 426_ LFTLG 431_ LAQCA 436_ QVMSL 441_ STILA 446_ AIVNH 451_ LQNSI 456_ QEDKL 461_ SGDRI 466_ KQVME 471_ HIWKL 476_ QEFCN 481_ SMAKL 486_ DIDGY 491_ EYAYL 496_ KAIVL 501_ FSPDH 506_ PGLTS 511_ TSQIE 516_ KFQEK 521_ AQMEL 526_ QDYVQ 531_ KTYSE 536_ DTYRL 541_ ARILV 546_ RLPAL 551_ RLMSS 556_ NITEE 561_ LFFTG 566_ LIGNV 571_ SIDSI 576_ IPYIL 581_ KMETA 586_ EYNGQ 591_ITGAS
1: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation