Natural resistance-associated macrophage protein 1 (NRAMP 1) (Solute carrier family 11 member 1)
1_MTGDK 6_ GPQRL 11_ SGSSY 16_ GSISS 21_ PTSPT 26_ SPGPQ 31_ QAPPR 36_ ETYLS 41_ EKIPI 46_ PDTKP 51_ GTFSL 56_ RKLWA 61_ FTGPG 66_ FLMSI 71_ AFLDP 76_ GNIES 81_ DLQAG 86_ AVAGF 91_ KLLWV 96_ LLWAT 101_ VLGLL 106_ CQRLA 111_ ARLGV 116_ VTGKD 121_ LGEVC 126_ HLYYP 131_ KVPRT 136_ VLWLT 141_ IELAI 146_ VGSDM 151_ QEVIG 156_ TAIAF 161_ NLLSA 166_ GRIPL 171_ WGGVL 176_ ITIVD 181_ TFFFL 186_ FLDNY 191_ GLRKL 196_ EAFFG 201_ LLITI 206_ MALTF 211_ GYEYV 216_ VARPE 221_ QGALL 226_ RGLFL 231_ PSCPG 236_ CGHPE 241_ LLQAV 246_ GIVGA 251_ IIMPH 256_ NIYLH 261_ SALVK 266_ SREID 271_ RARRA 276_ DIREA 281_ NMYFL 286_ IEATI 291_ ALSVS 296_ FIINL 301_ FVMAV 306_ FGQAF 311_ YQKTN 316_ QAAFN 321_ ICANS 326_ SLHDY 331_ AKIFP 336_ MNNAT 341_ VAVDI 346_ YQGGV 351_ ILGCL 356_ FGPAA 361_ LYIWA 366_ IGLLA 371_ AGQSS 376_ TMTGT 381_ YAGQF 386_ VMEGF 391_ LRLRW 396_ SRFAR 401_ VLLTR 406_ SCAIL 411_ PTVLV 416_ AVFRD 421_ LRDLS 426_ GLNDL 431_ LNVLQ 436_ SLLLP 441_ FAVLP 446_ ILTFT 451_ SMPTL 456_ MQEFA 461_ NGLLN 466_ KVVTS 471_ SIMVL 476_ VCAIN 481_ LYFVV 486_ SYLPS 491_ LPHPA 496_ YFGLA 501_ ALLAA 506_ AYLGL 511_ STYLV 516_ WTCCL 521_ AHGAT 526_ FLAHS 531_ SHHHF 536_ LYGLL 541_EEDQK
1: Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity (PubMed:11237855). Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (Probable)