Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2)
1_MVLGP 6_ EQKMS 11_ DDSVS 16_ GDHGE 21_ SASLG 26_ NINPA 31_ YSNPS 36_ LSQSP 41_ GDSEE 46_ YFATY 51_ FNEKI 56_ SIPEE 61_ EYSCF 66_ SFRKL 71_ WAFTG 76_ PGFLM 81_ SIAYL 86_ DPGNI 91_ ESDLQ 96_ SGAVA 101_ GFKLL 106_ WILLL 111_ ATLVG 116_ LLLQR 121_ LAARL 126_ GVVTG 131_ LHLAE 136_ VCHRQ 141_ YPKVP 146_ RVILW 151_ LMVEL 156_ AIIGS 161_ DMQEV 166_ IGSAI 171_ AINLL 176_ SVGRI 181_ PLWGG 186_ VLITI 191_ ADTFV 196_ FLFLD 201_ KYGLR 206_ KLEAF 211_ FGFLI 216_ TIMAL 221_ TFGYE 226_ YVTVK 231_ PSQSQ 236_ VLKGM 241_ FVPSC 246_ SGCRT 251_ PQIEQ 256_ AVGIV 261_ GAVIM 266_ PHNMY 271_ LHSAL 276_ VKSRQ 281_ VNRNN 286_ KQEVR 291_ EANKY 296_ FFIES 301_ CIALF 306_ VSFII 311_ NVFVV 316_ SVFAE 321_ AFFGK 326_ TNEQV 331_ VEVCT 336_ NTSSP 341_ HAGLF 346_ PKDNS 351_ TLAVD 356_ IYKGG 361_ VVLGC 366_ YFGPA 371_ ALYIW 376_ AVGIL 381_ AAGQS 386_ STMTG 391_ TYSGQ 396_ FVMEG 401_ FLNLK 406_ WSRFA 411_ RVVLT 416_ RSIAI 421_ IPTLL 426_ VAVFQ 431_ DVEHL 436_ TGMND 441_ FLNVL 446_ QSLQL 451_ PFALI 456_ PILTF 461_ TSLRP 466_ VMSDF 471_ ANGLG 476_ WRIAG 481_ GILVL 486_ IICSI 491_ NMYFV 496_ VVYVR 501_ DLGHV 506_ ALYVV 511_ AAVVS 516_ VAYLG 521_ FVFYL 526_ GWQCL 531_ IALGM 536_ SFLDC 541_ GHTCH 546_ LGLTA 551_ QPELY 556_ LLNTM 561_DADSL
1: Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:17109629, PubMed:17293870, PubMed:22736759, PubMed:25326704, PubMed:25491917). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (PubMed:17109629, PubMed:17293870, PubMed:22736759, PubMed:25326704, PubMed:25491917). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (By similarity) (PubMed:24448823). Can mediate uncoupled fluxes of either protons or metal ions