Nuclear autoantigenic sperm protein (NASP)
1_MAMES 6_ TATAA 11_ VAAEL 16_ VSADK 21_ IEDVP 26_ APSTS 31_ ADKVE 36_ SLDVD 41_ SEAKK 46_ LLGLG 51_ QKHLV 56_ MGDIP 61_ AAVNA 66_ FQEAA 71_ SLLGK 76_ KYGET 81_ ANECG 86_ EAFFF 91_ YGKSL 96_ LELAR 101_ MENGV 106_ LGNAL 111_ EGVHV 116_ EEEEG 121_ EKTED 126_ ESLVE 131_ NNDNI 136_ DEEAR 141_ EELRE 146_ QVYDA 151_ MGEKE 156_ EAKKT 161_ EDKSL 166_ AKPET 171_ DKEQD 176_ SEMEK 181_ GGRED 186_ MDISK 191_ SAEEP 196_ QEKVD 201_ LTLDW 206_ LTETS 211_ EEAKG 216_ GAAPE 221_ GPNEA 226_ EVTSG 231_ KPEQE 236_ VPDAE 241_ EEKSV 246_ SGTDV 251_ QEECR 256_ EKGGQ 261_ EKQGE 266_ VIVSI 271_ EEKPK 276_ EVSEE 281_ QPVVT 286_ LEKQG 291_ TAVEV 296_ EAESL 301_ DPTVK 306_ PVDVG 311_ GDEPE 316_ EKVVT 321_ SENEA 326_ GKAVL 331_ EQLVG 336_ QEVPP 341_ AEESP 346_ EVTTE 351_ AAEAS 356_ AVEAG 361_ SEVSE 366_ KPGQE 371_ APVLP 376_ KDGAV 381_ NGPSV 386_ VGDQT 391_ PIEPQ 396_ TSIER 401_ LTETK 406_ DGSGL 411_ EEKVR 416_ AKLVP 421_ SQEET 426_ KLSVE 431_ ESEAA 436_ GDGVD 441_ TKVAQ 446_ GATEK 451_ SPEDK 456_ VQIAA 461_ NEETQ 466_ EREEQ 471_ MKEGE 476_ ETEGS 481_ EEDDK 486_ ENDKT 491_ EEMPN 496_ DSVLE 501_ NKSLQ 506_ ENEEE 511_ EIGNL 516_ ELAWD 521_ MLDLA 526_ KIIFK 531_ RQETK 536_ EAQLY 541_ AAQAH 546_ LKLGE 551_ VSVES 556_ ENYVQ 561_ AVEEF 566_ QSCLN 571_ LQEQY 576_ LEAHD 581_ RLLAE 586_ THYQL 591_ GLAYG 596_ YNSQY 601_ DEAVA 606_ QFSKS 611_ IEVIE 616_ NRMAV 621_ LNEQV 626_ KEAEG 631_ SSAEY 636_ KKEIE 641_ ELKEL 646_ LPEIR 651_ EKIED 656_ AKESQ 661_ RSGNV 666_ AELAL 671_ KATLV 676_ ESSTS 681_ GFTPG 686_ GGGSS 691_ VSMIA 696_ SRKPT 701_ DGASS 706_ SNCVT 711_ DISHL 716_ VRKKR 721_ KPEEE 726_ SPRKD 731_ DAKKA 736_ KQEPE 741_ VNGGS 746_ GDAVP 751_ SGNEV 756_ SENME 761_ EEAEN 766_ QAESR 771_ AAVEG 776_ TVEAG 781_ATVES
1: Component of the histone chaperone network (PubMed:22195965). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:22195965). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA
2: Stabilizes soluble histone H3-H4
3: Stabilizes soluble histone H3-H4