Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]
1_MEEVV 6_ IAGMS 11_ GKLPE 16_ SENLQ 21_ EFWDN 26_ LIGGV 31_ DMVTD 36_ DDRRW 41_ KAGLY 46_ GLPRR 51_ SGKLK 56_ DLSRF 61_ DASFF 66_ GVHPK 71_ QAHTM 76_ DPQLR 81_ LLLEV 86_ TYEAI 91_ VDGGI 96_ NPDSL 101_ RGTHT 106_ GVWVG 111_ VSGSE 116_ TSEAL 121_ SRDPE 126_ TLVGY 131_ SMVGC 136_ QRAMM 141_ ANRLS 146_ FFFDF 151_ RGPSI 156_ ALDTA 161_ CSSSL 166_ MALQN 171_ AYQAI 176_ HSGQC 181_ PAAIV 186_ GGINV 191_ LLKPN 196_ TSVQF 201_ LRLGM 206_ LSPEG 211_ TCKAF 216_ DTAGN 221_ GYCRS 226_ EGVVA 231_ VLLTK 236_ KSLAR 241_ RVYAT 246_ ILNAG 251_ TNTDG 256_ FKEQG 261_ VTFPS 266_ GDIQE 271_ QLIRS 276_ LYQSA 281_ GVAPE 286_ SFEYI 291_ EAHGT 296_ GTKVG 301_ DPQEL 306_ NGITR 311_ ALCAT 316_ RQEPL 321_ LIGST 326_ KSNMG 331_ HPEPA 336_ SGLAA 341_ LAKVL 346_ LSLEH 351_ GLWAP 356_ NLHFH 361_ SPNPE 366_ IPALL 371_ DGRLQ 376_ VVDQP 381_ LPVRG 386_ GNVGI 391_ NSFGF 396_ GGSNV 401_ HIILR 406_ PNTQP 411_ PPAPA 416_ PHATL 421_ PRLLR 426_ ASGRT 431_ PEAVQ 436_ KLLEQ 441_ GLRHS 446_ QDLAF 451_ LSMLN 456_ DIAAV 461_ PATAM 466_ PFRGY 471_ AVLGG 476_ ERGGP 481_ EVQQV 486_ PAGER 491_ PLWFI 496_ CSGMG 501_ TQWRG 506_ MGLSL 511_ MRLDR 516_ FRDSI 521_ LRSDE 526_ AVKPF 531_ GLKVS 536_ QLLLS 541_ TDEST 546_ FDDIV 551_ HSFVS 556_ LTAIQ 561_ IGLID 566_ LLSCM 571_ GLRPD 576_ GIVGH 581_ SLGEV 586_ ACGYA 591_ DGCLS 596_ QEEAV 601_ LAAYW 606_ RGQCI 611_ KEAHL 616_ PPGAM 621_ AAVGL 626_ SWEEC 631_ KQRCP 636_ PGVVP 641_ ACHNS 646_ KDTVT 651_ ISGPQ 656_ APVFE 661_ FVEQL 666_ RKEGV 671_ FAKEV 676_ RTGGM 681_ AFHSY 686_ FMEAI 691_ APPLL 696_ QELKK 701_ VIREP 706_ KPRSA 711_ RWLST 716_ SIPEA 721_ QWHSS 726_ LARTS 731_ SAEYN 736_ VNNLV 741_ SPVLF 746_ QEALW 751_ HVPEH 756_ AVVLE 761_ IAPHA 766_ LLQAV 771_ LKRGL 776_ KPSCT 781_ IIPLM 786_ KKDHR 791_ DNLEF 796_ FLAGI 801_ GRLHL 806_ SGIDA 811_ NPNAL 816_ FPPVE 821_ FPAPR 826_ GTPLI 831_ SPLIK 836_ WDHSL 841_ AWDVP 846_ AAEDF 851_ PNGSG 856_ SPSAA 861_ IYNID 866_ TSSES 871_ PDHYL 876_ VDHTL 881_ DGRVL 886_ FPATG 891_ YLSIV 896_ WKTLA 901_ RALGL 906_ GVEQL 911_ PVVFE 916_ DVVLH 921_ QATIL 926_ PKTGT 931_ VSLEV 936_ RLLEA 941_ SRAFE 946_ VSENG 951_ NLVVS 956_ GKVYQ 961_ WDDPD 966_ PRLFD 971_ HPESP 976_ TPNPT 981_ EPLFL 986_ AQAEV 991_ YKELR 996_ LRGYD 1001_ YGPHF 1006_ QGILE 1011_ ASLEG 1016_ DSGRL 1021_ LWKDN 1026_ WVSFM 1031_ DTMLQ 1036_ MSILG 1041_ SAKHG 1046_ LYLPT 1051_ RVTAI 1056_ HIDPA 1061_ THRQK 1066_ LYTLQ 1071_ DKAQV 1076_ ADVVV 1081_ SRWLR 1086_ VTVAG 1091_ GVHIS 1096_ GLHTE 1101_ SAPRR 1106_ QQEQQ 1111_ VPILE 1116_ KFCFT 1121_ PHTEE 1126_ GCLSE 1131_ RAALQ 1136_ EELQL 1141_ CKGLV 1146_ QALQT 1151_ KVTQQ 1156_ GLKMV 1161_ VPGLD 1166_ GAQIP 1171_ RDPSQ 1176_ QELPR 1181_ LLSAA 1186_ CRLQL 1191_ NGNLQ 1196_ LELAQ 1201_ VLAQE 1206_ RPKLP 1211_ EDPLL 1216_ SGLLD 1221_ SPALK 1226_ ACLDT 1231_ AVENM 1236_ PSLKM 1241_ KVVEV 1246_ LAGHG 1251_ HLYSR 1256_ IPGLL 1261_ SPHPL 1266_ LQLSY 1271_ TATDR 1276_ HPQAL 1281_ EAAQA 1286_ ELQQH 1291_ DVAQG 1296_ QWDPA 1301_ DPAPS 1306_ ALGSA 1311_ DLLVC 1316_ NCAVA 1321_ ALGDP 1326_ ASALS 1331_ NMVAA 1336_ LREGG 1341_ FLLLH 1346_ TLLRG 1351_ HPLGD 1356_ IVAFL 1361_ TSTEP 1366_ QYGQG 1371_ ILSQD 1376_ AWESL 1381_ FSRVS 1386_ LRLVG 1391_ LKKSF 1396_ YGSTL 1401_ FLCRR 1406_ PTPQD 1411_ SPIFL 1416_ PVDDT 1421_ SFRWV 1426_ ESLKG 1431_ ILADE 1436_ DSSRP 1441_ VWLKA 1446_ INCAT 1451_ SGVVG 1456_ LVNCL 1461_ RREPG 1466_ GNRLR 1471_ CVLLS 1476_ NLSST 1481_ SHVPE 1486_ VDPGS 1491_ AELQK 1496_ VLQGD 1501_ LVMNV 1506_ YRDGA 1511_ WGAFR 1516_ HFLLE 1521_ EDKPE 1526_ EPTAH 1531_ AFVST 1536_ LTRGD 1541_ LSSIR 1546_ WVCSS 1551_ LRHAQ 1556_ PTCPG 1561_ AQLCT 1566_ VYYAS 1571_ LNFRD 1576_ IMLAT 1581_ GKLSP 1586_ DAIPG 1591_ KWTSQ 1596_ DSLLG 1601_ MEFSG 1606_ RDASG 1611_ KRVMG 1616_ LVPAK 1621_ GLATS 1626_ VLLSP 1631_ DFLWD 1636_ VPSNW 1641_ TLEEA 1646_ ASVPV 1651_ VYSTA 1656_ YYALV 1661_ VRGRV 1666_ RPGET 1671_ LLIHS 1676_ GSGGV 1681_ GQAAI 1686_ AIALS 1691_ LGCRV 1696_ FTTVG 1701_ SAEKR 1706_ AYLQA 1711_ RFPQL 1716_ DSTSF 1721_ ANSRD 1726_ TSFEQ 1731_ HVLWH 1736_ TGGKG 1741_ VDLVL 1746_ NSLAE 1751_ EKLQA 1756_ SVRCL 1761_ ATHGR 1766_ FLEIG 1771_ KFDLS 1776_ QNHPL 1781_ GMAIF 1786_ LKNVT 1791_ FHGVL 1796_ LDAFF 1801_ NESSA 1806_ DWREV 1811_ WALVQ 1816_ AGIRD 1821_ GVVRP 1826_ LKCTV 1831_ FHGAQ 1836_ VEDAF 1841_ RYMAQ 1846_ GKHIG 1851_ KVVVQ 1856_ VLAEE 1861_ PEAVL 1866_ KGAKP 1871_ KLMSA 1876_ ISKTF 1881_ CPAHK 1886_ SYIIA 1891_ GGLGG 1896_ FGLEL 1901_ AQWLI 1906_ QRGVQ 1911_ KLVLT 1916_ SRSGI 1921_ RTGYQ 1926_ AKQVR 1931_ RWRRQ 1936_ GVQVQ 1941_ VSTSN 1946_ ISSLE 1951_ GARGL 1956_ IAEAA 1961_ QLGPV 1966_ GGVFN 1971_ LAVVL 1976_ RDGLL 1981_ ENQTP 1986_ EFFQD 1991_ VCKPK 1996_ YSGTL 2001_ NLDRV 2006_ TREAC 2011_ PELDY 2016_ FVVFS 2021_ SVSCG 2026_ RGNAG 2031_ QSNYG 2036_ FANSA 2041_ MERIC 2046_ EKRRH 2051_ EGLPG 2056_ LAVQW 2061_ GAIGD 2066_ VGILV 2071_ ETMST 2076_ NDTIV 2081_ SGTLP 2086_ QRMAS 2091_ CLEVL 2096_ DLFLN 2101_ QPHMV 2106_ LSSFV 2111_ LAEKA 2116_ AAYRD 2121_ RDSQR 2126_ DLVEA 2131_ VAHIL 2136_ GIRDL 2141_ AAVNL 2146_ DSSLA 2151_ DLGLD 2156_ SLMSV 2161_ EVRQT 2166_ LEREL 2171_ NLVLS 2176_ VREVR 2181_ QLTLR 2186_ KLQEL 2191_ SSKAD 2196_ EASEL 2201_ ACPTP 2206_ KEDGL 2211_ AQQQT 2216_ QLNLR 2221_ SLLVN 2226_ PEGPT 2231_ LMRLN 2236_ SVQSS 2241_ ERPLF 2246_ LVHPI 2251_ EGSTT 2256_ VFHSL 2261_ ASRLS 2266_ IPTYG 2271_ LQCTR 2276_ AAPLD 2281_ SIHSL 2286_ AAYYI 2291_ DCIRQ 2296_ VQPEG 2301_ PYRVA 2306_ GYSYG 2311_ ACVAF 2316_ EMCSQ 2321_ LQAQQ 2326_ SPAPT 2331_ HNSLF 2336_ LFDGS 2341_ PTYVL 2346_ AYTQS 2351_ YRAKL 2356_ TPGCE 2361_ AEAET 2366_ EAICF 2371_ FVQQF 2376_ TDMEH 2381_ NRVLE 2386_ ALLPL 2391_ KGLEE 2396_ RVAAA 2401_ VDLII 2406_ KSHQG 2411_ LDRQE 2416_ LSFAA 2421_ RSFYY 2426_ KLRAA 2431_ EQYTP 2436_ KAKYH 2441_ GNVML 2446_ LRAKT 2451_ GGAYG 2456_ EDLGA 2461_ DYNLS 2466_ QVCDG 2471_ KVSVH 2476_ VIEGD 2481_ HRTLL 2486_ EGSGL 2491_ ESIIS 2496_ IIHSS 2501_ LAEPR 2506_VSVRE
1: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain
2: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication